Initial experience with antiarrhythmic medication monitoring by clinical pharmacists in an outpatient setting: a retrospective review. Snider M, Kalbfleisch S, Carnes CA.Clin Ther. 2009 Jun;31(6):1209-18.

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death. Belevych AE, Terentyev D, Viatchenko-Karpinski S, Terentyeva R, Sridhar A, Nishijima Y, Wilson LD, Cardounel AJ, Laurita KR, Carnes CA, Billman GE, Gyorke S. Cardiovasc Res. 2009 Aug 14.

Chronic heart failure and the substrate for atrial fibrillation. Sridhar A, Nishijima Y, Terentyev D, Khan M, Terentyeva R, Hamlin RL, Nakayama T, Gyorke S, Cardounel AJ, Carnes CA. Cardiovasc Res. 2009 Nov 1;84(2):227-36. Epub 2009 Jun 30.

Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure. Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S. Circ Res. 2008 Dec 5;103(12):1466-72. Epub 2008 Nov 13.

Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction. Mohan IK, Khan M, Wisel S, Selvendiran K, Sridhar A, Carnes CA, Bognar B, Kálai T, Hideg K, Kuppusamy P. Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H140-51. Epub 2008 Oct 31.

Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death. Sridhar A, Nishijima Y, Terentyev D, Terentyeva R, Uelmen R, Kukielka M, Bonilla IM, Robertson GA, Györke S, Billman GE, Carnes CA. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1463-72. Epub 2008 Sep 3.

Gyorke S, Carnes CA. Dysregulated Sarcoplasmic Reticulum Calcium Release: Potential Pharmacological Target in Cardiac Disease (review). In press, Pharmacology and Therapeutics 2008.

Snider M, Boyd M, Carnes CA. Amiodarone Use in Three Patients with Documented Hypersensitivity to Intravenous Contrast Dye (letter). Ann Pharmacother 2008; 42: 1349-50.

Lacombe VA, Viatchenko-Karpinski S, Terentyev D, Sridhar A, Emani S, Bonagura JD, Feldman DS, Gyorke S, Carnes CA. Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol 2007; Nov;293(5):R1787-97.

Belevych A, Kubalova Z, Terentyev D, Hamlin RL, Carnes CA, Gyorke S. Enhanced Ryanodine Receptor-Mediated Calcium Leak Determines Reduced Sarcoplasmic Reticulum Calcium Content in Chronic Canine Heart Failure. Biophys J 2007; 11:4083-92.

Holycross BJ, Kukielka M, Nishijima Y, Altschuld RA, Carnes CA, Billman GE. Exercise Training Normalizes {beta}-adrenoceptor Expression in Dogs Susceptible to Ventricular Fibrillation. Am J Physiol Heart Circ Physiol 2007;293:H2702-9.

Nishijima Y,Sridhar A, Viatchenko-Karpinski S, Shaw C, Bonagura JD, Abraham WT , Joshi MS, Bauer JA, Hamlin RL, Györke S, Feldman DS, Carnes CA. Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy. Life Sci 2007; 81: 1152-9.

Carnes CA, Janssen PML, Ruehr ML Nakayama H, Nakayama T, Haase H, Bauer JA, Chung MK, Fearon IM, Gillinov M, Hamlin RL, Van Wagoner DR. Atrial glutathione content, calcium current and contractility. J Biol Chem 2007; 282(38):28063-28073.

Mandal R, Kutala VK, Khan M, Mohan IK, Varadharaj S, Sridhar A, Carnes CA, Kálai T, Hideg K, Kuppusamy K. A Pro-nitroxyl Modification of Verapamil Exhibits Antioxidant Protection of Heart against Ischemia/Reperfusion-induced Cardiac Dysfunction without compromising Calcium Antagonistic Activity, J Pharm Exp Ther 2007; 323: 119-127.

Sridhar A, da Cunha DNQ, Lacombe VA, Zhou Q, Fox JJ, Hamlin RL, Carnes CA. 4-Aminopyridine-Sensitive Plateau Outward Current in Canine Ventricle: A Constitutive Contributor to Ventricular Repolarization, Br J Pharmacol 2007;152:870-9.

Babu GJ, Bhupathy P, Carnes CA, Billman GE, Periasamy M.  Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology, J Mol Cell Cardiol  (2007), doi: 10.1016/j.yjmcc.2007.05.009.

Dirksen WP, Lacombe VA, Chi M, Kalyanasundaram A, Viatchenko-Karpinski S, Terentyev D, Carnes CA, Chiamvimonvat N, Gyorke S., Periasamy M. A mutation in calsequestrin CSQD307H impairs SR calcium storage and release functions and causes polymorphic ventricular tachycardia in mice. Cardiovascular Research, in press, 2007.

Schwarzwald CC, Hamlin RL, Bonagura JD, Nishijima Y, Meadows C, Carnes CA. Atrial, SA nodal, and AV nodal electrophysiology in standing horses:  Normal findings and electrophysiologic effects of quinidine and diltiazem. J Vet Intern Med, 2007 Jan-Feb;21(1):166-75.

da Cunha DNQ, Hamlin RL, Billman GE, Carnes CA.  n-3 Polyunsaturated Fatty Acids Prevent Acute Atrial Electrophysiologic Remodeling. Br J Pharmacol 2007; 150: 281-5.

Sridhar A, Dech SJ, Lacombe VA, Elton TS, McCune SA, Altschuld RA, Carnes CA.  Abnormal diastolic currents in ventricular myocytes from spontaneous hypertensive and heart failure (SHHF) rats. Am J Physiol Heart Circ Physiol. 2006; 291(5):H2192-8.

Kubalova Z, Terentyev D, Viatchenko-Karpinski S, Nishijima Y, Gyorke I, Terentyeva R, da Cuñha D, Sridhar A, Feldman DS, Hamlin RL, Carnes CA, Gyorke S.  Abnormal intra-store calcium signaling in chronic heart failure.  Proc Natl Acad Sci U S A. 2005;102:14104-9.

Feldman DS, Carnes CA, Abraham WT, Bristow MR.  Mechanisms of Disease: b-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure (review).  Nature Clin Pract Cardiovasc Med 2005; 2: 475-83.

Nishijima Y, Feldman DS, Bonagura J, Ozkanlar Y, Jenkins PJ, Abraham WT, Hamlin RL, Carnes CA. Canine Nonischemic Left Ventricular Dysfunction: A Model of Chronic Human Cardiomyopathy. J Card Failure, 2005 Oct;11(8):638-44.

Carnes CA , Geisbuhler T, Reiser PJ. Age-dependent changes in contraction and regional myocardial myosin heavy chain isoform Expression in Rats . J Appl Physiol. 2004 Jul;97(1):446-53.

Carnes CA , Pickworth KK, Votolato NA, Raman SV. Elevated defibrillation threshold with venlafaxine therapy. Pharmacotherapy 2004; 24: 1095-8.

Chaves A, Dech SJ, Nakayama T, Hamlin RL, Bauer JA, Carnes CA. Age and Anesthetic Effects on Murine Electrocardiography. Life Sciences 2003 72: 2401-2412.

Hamlin RL, Nakayama T, Nakayama H, Carnes CA. Effects of changing heart rate on hemodynamic and electrophysiological parameters of cardiovascular function in the dog. Life Sciences 2003; 72: 1919-1930.

Carnes CA , and Dech SJ. Dihydrotestosterone and cardiac inward rectifier potassium current. Int J Androl 2002; 25: 210-4.

Nakayama H, Nakayama T, Carnes CA, Strauch SM, Hamlin RL.
Electrophysiologic and hemodynamic effects of apomorphine in dogs. Toxicol
Appl Pharmacol 2001; 177: 157-161.

Chung MK, Martin DO, Sprecher D, Wazni O, Kanderian A, Carnes CA, Bauer JA,
Tchou PJ, Niebauer MJ, Natale A, Van Wagoner DR. C-reactive protein
elevation in patients with atrial arrhythmias: Inflammatory mechanisms and
persistence of atrial fibrillation. Circulation 2001; 104: 2886-2891.

Carnes CA, Chung MK, Nakayama T, Nakayama H, Baliga RS, Piao S, Kanderian A, Pavia S, Hamlin RL, McCarthy PM, Bauer JA, Van Wagoner DR. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res 2001; 89: e32-e38.

Okamoto Y, Chaves A, Chen Y, Kelley R, Jones K, Weed HG, Gardner KL, Gangi L, Yamaguchi M, Klomkleaw W, Nakayama T, Hamlin RL, Carnes CA, Altschuld RA, Bauer JA, and Hai T. Transgenic mice expressing ATF3 in the heart have conduction abnormalities and contractile dysfunction. Am. J. Pathol. 2001; 159:639-650.

Mihm, M.J., F. Yu, C.A. Carnes, P.J. Reiser, P.M. McCarthy, D.R. Van Wagoner, J.A. Bauer, Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation 2001;104:174-180.

Carnes CA, Mehdirad AA. Effects of Acidemia, Azimilide and the Combination on Defibrillation Energy Requirements. J Cardiovasc Pharmacol 2000; 36: 283-287.

Wolfe TA, Carnes CA. Comparison of web-based and classroom instruction within a Pharm.D. therapeutics course. J Pharm Teaching 1999; 7: 59-67.

Mehdirad AA, Carnes CA, Nelson SD. The influence of specific and non-specific potassium current blockade on defibrillation energy requirements. PACE 1999; 22: 147-151.

Carnes CA, Mehdirad AA, Nelson SD. Drug and defibrillator interactions (review). Pharmacotherapy 1998; 18: 516-525.

Carnes CA, Muir WW, Van Wagoner DR. Effect of intravenous anesthetics on inward rectifier potassium current in rat and human ventricular myocytes. Anesthesiology 1997; 87: 327-334.

Coyle JD, Carnes CA, Schaal SF. Evaluation of an open-loop computer-based infusion system designed to achieve and maintain a series of constant, targeted plasma concentrations of procainamide in patients undergoing electrophysiology study, Pharmacotherapy 1997; 17: 445-456.

Coyle JD, Carnes CA, Schaal SF, Muir WW. Electrophysiologic interactions of procainamide and N-acetylprocainamide in isolated canine cardiac Purkinje fibers. J Cardiovasc Pharmacol 1992: 20: 197-205.

Carnes CA and Coyle JD. Evaluation of very rapid EMIT Qst methods for measuring serum procainamide and N-acetylprocainamide concentrations. Pharmacotherapy 1992: 12: 40-44.

Carnes CA and Coyle JD. Moricizine: A novel antiarrhythmic agent (review). DICP, Ann Pharmacother 1990; 24: 745-753.

 

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