photo of Dr. Carcache

Esperanza J. Carcache de Blanco, PhD

Assistant Professor,
Division of Pharmacy Practice and Administration,
Division of Medicinal Chemistry

Parks Hall Room 141N
500 West 12th Avenue
Columbus, OH 43210

E-mail: carcache@pharmacy.ohio-state.edu
Phone: (614) 247-7815, Fax: (614) 292-1335

PPAD / Pharmacy Practice / Faculty and Research / Esperanza J. Carcache de Blanco

 

Education

  • PhD in Pharmacognosy, 2003, University of Illinois at Chicago
  • Master of Science in Pharmacognosy, 1997, University of Illinois at Chicago
  • BS in Pharmacy, 1986, National Autonomous University of Nicaragua

Areas of Interest

  • Dietary Supplements
  • Traditional Medicine
  • Natural Products Drug Discovery

Representative Publications

Kim JA, Lau EKC, Tay D, and Carcache de Blanco EJ. 2008. Chemical constituents from Morchella esculenta Pers. (Morchellaceae). Nat. Prod. Lett. Part B (In press). (Forthcoming) (IF: 0.683)

Kim JA, Tay D, and Carcache de Blanco EJ. 2008. NF-kB inhibitory activity of compounds isolated from Cantharellus cibarius. Phytother. Res., 22: 1104-1106. (IF: 1.430)

Salim AA, Chai H-B, Rachman I, Riswan S, Kardono LBS, Farnsworth NR, Carcache-Blanco EJ, and Kinghorn AD. 2007. Constituents of the Leaves and Stem Bark of Aglaia foveolata. Tetrahedron, 63: 7926-7934. (IF: 2.869)

Carcache de Blanco EJ, Pandit B, Hu Z, Shi J, Lewis A, Li P-K. 2007. Inhibitors of NF-kB derived from Thalidomide. Bioorg. Med. Chem., 17: 6031-6035. (IF: 2.662)

Salim AA, Pawlus AD, Chai H-B, Farnsworth NR, Kinghorn AD, Carcache-Blanco EJ. 2007. Ponapensin, a cyclopenta[bc]benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis. Bioorg. Med. Chem. Lett., 17: 109-112. (IF: 2.604)

Carcache-Blanco EJ, Misico R, Park EJ, Cuendet M, Farnsworth NR, Pezzuto JM, Kinghorn AD. 2006. Bioactive constituents from Arbutus unedo that inhibit the transformation of JB6 murine epidermal cells and the enzyme cyclooxygenase-2 (COX-2). Nat. Prod. Res., Part B., 20: 327-334. (IF: 0.798)

Su, B.-N., Hwang, B. Y., Carcache-Blanco, E. J., Chai, H., Kardono, L. B. S., Afriastini, J. J., Riswan, S., Wild, R., Liang, N., Farnsworth, N. R., Cordell, G. A., Swanson, S. M., and Kinghorn, A. D.: Fractionation of the leaves of Ormosia sumatrana using a proteasome inhibition assay. J. Nat. Prod.67: 1911-1914, 2004.

Carcache-Blanco, E. J ., Misico, R., Park, E. J., Cuendet, M., Farnsworth, N. R., Pezzuto, J. M., and Kinghorn, A. D.: Bioactive constituents from Arbutus unedo that inhibit the transformation of JB6 murine epidermal cells and the enzyme cyclooxygenase-2 (COX-2). Nat. Prod. Res.

Kinghorn, A. D., Su, B.-N., Jang, D. S., Chang, L. C., Le, D., Gu, J.-Q., Carcache-Blanco, E. J., Pawlus, A. D., Lee, S. K., Park, E. J., Cuendet, M., Gills, J. J., Bhat, K., Park, H.-S., Mata-Greenwood, E., Song, L., Jang, M., and Pezzuto, J. M.: Natural inhibitors of carcinogenesis. Planta Med.70: 691-705, 2004.

Carcache-Blanco, E. J ., Kang, Y. H., Park, E. J., Su, B.-N., Kardono, L. B. S., Riswan, S., Fong, H. H. S., Pezzuto, J. M. and Kinghorn, A. D.: Constituents of the bark of Pongamia pinnata with the potential to induce quinone reductase. J. Nat. Prod. 66: 1197-1202, 2003.

Lee, S. K., Mbwambo, Z. H., Chung, H., Luyengi, L., Gamez, E. J. C., Mehta, R. G., Kinghorn, A. D., and Pezzuto, J. M.: Evaluation of the antioxidant potential of natural products. Combin. Chem. High Throughput Screen.1: 35-46, 1998.

Gamez, E. J. C ., Luyengi, L., Lee, S. K., Zhu, L.-F., Zhou, B.-N., Fong, H. H. S., Pezzuto, J. M., and Kinghorn, A. D.: Antioxidant flavonoid glycosides fromDaphniphyllum calycinum. J. Nat. Prod. 61: 706-708, 1998.

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Presentations at Scientific Meetings

2005 Carcache-Blanco, E. J., Su, B.-N., Riswan, S., Kardono, L. B.S., Rachman, I., Chai, H.-B., Orjala, J., Farnsworth, N. R., Cordell, G. A., Kinghorn, A. D., and Swanson, S. M.: Morelloflavone, a proteasome inhibitor from the stem bark of Garcinia lateriflora, 46 th Annual ASP Meeting, Corvalisx, OR, July 23-27, 2005; Poster.

2005 Balunas, M. J., Su, B.-N., Landini, S., Carcache-Blanco, E. J., Swanson, S. M., Brueggemeier, R. W., and Kinghorn, A. D.: Interference by naturally occurring fatty acids in a non-cellular, enzyme-based aromatase bioassay, 46 th Annual ASP Meeting, Corvalisx, OR, July 23-27, 2005; Poster.

2004 Carcache-Blanco, E. J., Su, B.-N., Riswan, S., Ismail, R., Farnsworth, N. R., Cordell, G. A., Orjala, J., Swanson, S. M., and Kinghorn, A. D.: Fractionation of the bark of Elmerrillia ovalis using a histone deacetylase inhibition assay, 45 th Annual ASP Meeting, Phoenix, AZ, July 31-August 4, 2004; Poster.

2004 Su, B.-N., Hwang, B. Y., Carcache-Blanco, E. J., Chai, H., Kardono, L. B. S., Afriastini, J. J., Riswan, S., Wild, R., Liang, N., Farnsworth, N. R., Cordell, G. A., Swanson, S. M., and Kinghorn, A. D.: Fractionation of the leaves of Ormosia sumatrana using a proteasome inhibition assay, 45 th Annual ASP Meeting, Phoenix, AZ, July 31-August 4, 2004; Poster.

2003 Carcache-Blanco, E. J., Kang, Y. H., Park, E. J., Su, B. N., Kardono, L. B. S., Riswan, S., Fong, H. H. S., Pezzuto, J. M., and Kinghorn, A. D.: Bioactive flavonoid constituents of Pongamia pinnata, 40 th Annual Medicinal Chemistry Meeting-in-Miniature, University of Kansas, Lawrence, KS, March 28-30, 2003; Oral Presentation.

2002 Carcache de Blanco, E. J., Misico, R., Park, E. J., Cuendet, M., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D.: Bioactive constituents from arbutus unedo that inhibit the transformation of JB6 murine epidermal cells and the enzyme cyclooxygenase-2 (COX-2), 40 th Annual Medicinal Chemistry Meeting-in-Miniature, University of Illinois at Chicago, Chicago, IL, April 12-14, 2002; Poster.

Invited Presentations

2003 Carcache-Blanco, E. J., Kang, Y. H., Park, E. J., Su, B. N., Kardono, L. B. S., Riswan, S., Fong, H. H. S., Pezzuto, J. M., and Kinghorn, A. D. CONSTITUENTS OF THE STEM BARK OF PONGAMIA PINNATA WITH THE POTENTIAL TO INDUCE QUINONE REDUCTASE, 44 th Annual ASP Meeting, Chapel Hill, NC, July 12-16, 2003; Oral Presentation.

2003 Carcache-Blanco, E. J., Kang, Y. H., Park, E. J., Su, B.-N., Kardono, L. B. S., Riswan, S., Fong, H. H. S., Pezzuto, J. M. and Kinghorn, A. D.: COMPONENTES DEL PONGAMIA PINNATA CON EL POTENCIAL DE INDUCIR LA ENZIMA QUINONA REDUCTASA EN LA BÚSQUEDA DE PREVENTIVOS DEL CÁNCER, School of Pharmacy, National Autonomous University of Nicaragua (UNAN), León, Nicaragua, December 22, 2003; Oral Presentation.

Honors & Awards

2003-2005 Posdoctoral Fellowship Award, National Cancer Institute, National Cooperative Drug Discovery Group (NCDDG) project “Novel Strategies for Plant-Derived Anticancer Agents”, College of Pharmacy, University of Illinois at Chicago (UIC), (Research Supplements for Under-represented Minorities Award) (3U19 CA52956-14S1 to Dr. A. D. Kinghorn as Principal Investigator)

2003 Student Research Award, The American Society of Pharmacognosy, 44th Annual ASP Meeting, Chapel Hill, NC

2002 Van Doren Scholar, College of Pharmacy, University of Illinois at Chicago, (Outstanding Graduate Student in the Department of Medicinal Chemistry and Pharmacognosy)

2002 UIC Health Science Auxiliary Award Fellowship, UIC (Outstanding Graduate Student in the Health Sciences)

1997 J. William Fulbright Foreign Scholarship Board and United States Information Agency Award, Washington, DC

1988 Outstanding Instructor, Asociación Nicaragüense de Educadores de Nicaragua

1986 Outstanding Undergraduate Student from School of Pharmacy, UNAN-León, León, Nicaragua

1986 Outstanding Teaching Assistant, UNAN-León, León, Nicaragua

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