Education

• Post-Doctoral Fellow/Research Scientist, 1996-2001, Department of Pharmacology, University of Pittsburgh School of Medicine and Department of Neurology, The Ohio State University College of Medicine
  
  
• PhD, 1996, Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA (Advisor, I.J. Reynolds)

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Research Interests

We are investigating neuroprotective signaling pathways in acute and chronic models of neurodegeneration (Parkinson’s, Huntington’s, stroke, seizures, and fetal alcohol syndrome).  In particular, we are manipulating neuronal antioxidant response element- and cyclic AMP response element-mediated transcription using newly generated transgenic mouse models.  These novel transgenic mice are facilitating our studies of the role of these signaling pathways in neurodegeneration, neurogenesis, and neuroprotection.  In addition, we are investigating the pathologic processes that lead to neuronal loss. Calcium deregulation, oxidative stress and mitochondrial dysfunction are among the causes often implicated in neuronal death, and are also under study in the lab.  Overall, we seek to understand both the molecular events contributing to neurodegeneration as well as the mechanisms by which neurons attempt to protect themselves from such damage.  Our goal is to develop therapeutic strategies, based on modulation of these signaling pathways, for the prevention/treatment of these devastating neurodegenerative diseases. 

Publications (link to search of US National Library of Medicine (NLM) and PubMed)

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Teaching

Pharmacy 749:  CNS Pharmacology (Pharmacology III), Course Director

Pharmacy 873:  Contemporary Pharmacology, Course Director

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Professional Experience

2007-present: Associate Professor, Division of Pharmacology, The Ohio State University; Faculty member in the Neurosciences Graduate Studies Program.

2001-2007: Assistant Professor, Division of Pharmacology, The Ohio State University; Faculty member in the Neurosciences Graduate Studies Program.

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