Education

• Postdoctoral Fellowship, University of Minnesota Hospitals, Minneapolis, MN.
• PhD, Pharmaceutics, State University of New York at Buffalo.
• BS, State University of New York at Buffalo.

---

Areas of Interest

Dr. Bauer's overall research goal is to investigate mechanisms of disease for rational improvements in therapy. His current research projects involve understanding the contributions oxidants and inflammatory pathways in the initiation and progression of cardiac and vascular disease. His research group is particularly interested in identifying the earliest events involved in the disease processes with hope to develop prevention strategies and identify markers of patient risk (biochemical markers of genetic predispositions). Dr. Bauer's group also has active collaborations with other researchers and clinicians at the Columbus Children’s Hospital and Research Institute. Some current projects include:

1. Defining the roles and mechanisms of biological oxidation in chronic disease: We have been actively investigating the relevance of peroxynitrite in disease. This powerful reactive nitrogen species is formed by the interaction of nitric oxide with superoxide anion, and is now recognized as an important contributor to cellular dysfunction and tissue injury in a wide array of disease states. We are asking the following questions: what are the mechanisms of peroxynitrite formation? What are the key protein targets and cellular consequences? And how do reactive nitrogen species toxicities differ from reactive oxygen species? What are the genetic determinants of these phenomena (particularly involving nitric oxide synthase and superoxide dismutase isoform polymorphisms).
2. Investigating mechanisms involved in various forms cardiac failure, particularly in relation to cardiac myocyte inflammation and signalling.
3. Studying the roles and mechanisms of endothelial cell injury and dysfunction as a key initator of early cardiovascular disease in children, especially in diabetes and other settings of increased risk.

---

Publications

• Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen. Park, M.S., Rieger-Fackeldey, E., Schanbacher, B.L., Cook, A.C., Bauer, J.A., Rogers, L.K., Hansen, T.N., Welty, S.E., Smith, C.V. Pediatr Res. 62(6): 652-7, 2007.
• Bench-to-bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis. Luce, W.A., Hoffman, T.M., Bauer, J.A. Crit Care. 11(5): 228, 2007..
• Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy. Nishijima, Y., Sridhar, A., Viatchenko-Karpinski, S., Shaw, C., Bonagura, J.D., Abraham, W.T., Joshi, M.S., Bauer, J.A., Hamlin, R.L., Györke, S., Feldman, D.S., Carnes, C.A. Life Sci. 81(14): 1152-9, 2007.
• Bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation. Ma, T.C., Mihm, M.J., Bauer, J.A., Hoyt, K.R. J Neurochem. 103(1): 131-44, 2007.
• Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats. Chicoine, L.G., Paffett, M.L., Girton, M.R., Metropoulus, M.J., Joshi, M.S., Bauer, J.A., Nelin, L.D., Resta, T.C., Walker, B.R. Am J Physiol Lung Cell Mol Physiol. 293(5): L1261-70, 2007.
• Atrial glutathione content, calcium current, and contractility. Carnes, C.A., Janssen, P.M., Ruehr, M.L., Nakayama, H., Nakayama, T., Haase, H., Bauer, J.A., Chung, M.K., Fearon, I.M., Gillinov, A.M., Hamlin, R.L., Van Wagoner, D.R. J Biol Chem. Sep 21; 282(38): 28063-73, 2007.
• Effects of hyperoxia on postnatal intestinal development. Giannone, P.J., Bauer, J.A., Schanbacher, B.L., Reber, K.M. Biotech Histochem. Feb; 82(1): 17-22, 2007.
• Pediatric precursors of adult cardiovascular disease: noninvasive assessment of early vascular changes in children and adolescents. Pediatrics. Oct;118(4):1683-91, 2006.
• Effects of prenatal lipopolysaccharide exposure on epithelial development and function in newborn rat intestine. J Pediatr Gastroenterol Nutr. Sep;43(3):284-90, 2006. Innervation and connexin isoform expression during diabetes-related bladder dysfunction: early structural vs. neuronal remodelling. Poladia, D.P., Schanbacher, B., Wallace, L.J. and Bauer, J.A. Acta Diabetologica 42(3): 147-152, 2005.
• Link between reduced nephron number and hypertension: studies in a mutant mouse model. Poladia, D., Kish, K., Kutay, B., Bauer, J.A., Baum, M., Bates, C.M. Pediatric Res. 59(4 part 1): 489-93, 2006.
• MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. Zhao, Q., Wang, X.X., Nelin, L.D., Yao, Y.X., Matta, R., Manson, M.E., Baliga, R.S., Meng, X.M., Smith, C.V., Bauer, J.A., Chang, C.H. and Liu, Y.S. Journal Of Experimental Medicine 203(1): 131-140, 2006.
• Nitric oxide in the urinary bladder: involvement of autorelaxation. Poladia, D.P. and Bauer, J.A. Nitric Oxide-Biol. Chem. 10(1): 51-52, 2004.
• Selective microembolization of the circumflex coronary artery in an ovine model: Dilated, ischemic cardiomyopathy and left ventricular dysfunction. Monreal, G., Gerhardt, M.A., Kambara, A., Abrishamchian, A.R., Bauer, J.A. and Goldstein, A.H. J. Card. Fail. 10(2): 174-183, 2004.
• Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia. Crouser, E.D., Julian, M.W., Huff, J.E., Joshi, M.S., Bauer, J.A., Gadd, M.E., Wewers, M.D. and Pfeiffer, D.R. Crit. Care Med. 32(2): 478-488, 2004.
• Cardiomyopathy in a murine model of AIDS: evidence of reactive nitrogen species and corroboration in human HIV/AIDS cardiac tissues. Chaves, A.A., Mihm, M.J., Schanbacher, B.L., Basuray, A., Liu, C., Ayers, L.W. and Bauer, J.A. Cardiovasc. Res. 60(1): 108-118, 2003.

---

Professional Experience

• Division of Pharmacology/College of Pharmacy, The Ohio State University, October 1996-present (currently Adjunct Associate Professor)

---

© 2009 The Ohio State University  

If you have trouble accessing this page and need to request an alternate format, contact: webmaster@pharmacy.ohio-state.edu