Hu, L.; Arafa, R.; Ismail, M.; Wenzler, T.; Brun, R.; Munde, M.; Wilson, W.; Nzimiro, S.; Samyesudhas, S.; Werbovetz, K.; Boykin, D. Azaterphenyl Diamidines as Antileishmanial Agents, Bioorg. Med. Chem. Lett., in press.
Bakunova, S.; Bakunov, S.; Wenzler, T.; Barszcz, T.; Werbovetz, K.; Brun, R.; Hall, J.; Tidwell, R. Synthesis and In Vitro Antiprotozoal Activity of Bisbenzofuran Cations, J. Med. Chem., 2007, 50, 5807-5823.
George, T.; Endeshaw, M.; Morgan, R.; Mahasenan, K.; Delfín, D.; Mukherjee, M.; Yakovich, A.; Fotie, J.; Li, C.; Werbovetz, K. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4, N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents, Bioorg. Med. Chem., 2007, 15, 6071-6079.
Gonzalez, J.; Stephens, C.; Wenzler, T.; Brun, R.; Tanious, F.; Wilson, W.; Barszcz, T.; Werbovetz, K.; Boykin, D.Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes, Eur. J. Med. Chem., 2007, 42, 552-557.
Gutteridge, C.; Vo, J.; Tillett, C.; Vigilante, J.; Dettmer, J.; Patterson, S.; Werbovetz, K.; Capers, J.; Nichols, D.; Bhattacharjee, A.; Gerena, L. Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of pyridinyl and naphthalenyl analogs, Med. Chem., 2007, 3, 115-119.
Yakovich, A.; Ragone, F.; Alfonzo, J.; Sackett, D.; Werbovetz, K. Leishmania
tarentolae: Purification and characterization of tubulin and its suitability for antileishmanial drug screening. Exp. Parasitol., 2006, 114, 289-296.
Wu, D.; George, T.; Hurh, E.; Werbovetz, K.; Dalton, J. Pre-systemic metabolism prevents in vivo antikinetoplastid activity of N1, N4-substituted 3,5-dinitro sulfanilamide, GB-II-150. Life Sciences, 2006, 79, 1081-1093.
Delfn, D.; Bhattacharjee, A.; Yakovich, A; Werbovetz, K. Activity of and initial mechanistic studies on a novel antileishmanial agent identified through in silico pharmacophore development and database searching. J. Med. Chem., 2006, 49, 4196-4207.
George, T; Johnsamuel, J; Delfín, D.; Yakovich, A.; Mukherjee, M.; Phelps, M.; Dalton, J.; Sackett, D.; Kaiser, M.; Brun, R.; Werbovetz, K. Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides, Bioorg. Med. Chem., 2006, 14, 5699-5710.
Salem, M.; Werbovetz, K. Natural products from plants as drug candidates and
lead compounds against leishmaniasis and trypanosomiasis. Curr. Med. Chem., 2006, 13, 2571-2598.
Das, U.; Gul, I.; Alcorn, J.; Shrivastay, J.; George, T.; Sharma, R.; Nienaber, K.; De Clercq, E.; Balzarini, J.; Kawase, M.; Kan, N.; Tanaka, T.; Tani, S.; Werbovetz, K.; Yakovich, A.; Manavathu, E.; Stables, J.; Dimmock, J. Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. Eur. J. Med. Chem., 2006, 41, 577-585.
Salem, M.; Werbovetz, K. Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. J. Nat. Prod., 2006, 69, 43-49.
Li, P.; Pandit, B.; Sackett, D.; Hu, Z.; Zink, J.; Zhi, J.; Freeman, D.; Robey, R.; Werbovetz, K.; Lewis, A.; Li, C. A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities. Mol. Cancer Ther., 2006, 5, 450-456.
Li, P.; Xiao, Z.; Hu, Z.; Pandit, B.; Sun, Y.; Sackett, D.; Werbovetz, K.; Lewis, A.; Johnsamuel, J. Conformationally restricted analogs of combretastatin A-4 derived from SU5416. Bioorg. Med. Chem. Lett., 2005, 15, 5382-5385.
Salem, M.; Werbovetz, K. Antiprotozoal compounds from Psorothamnus polydenius, J. Nat. Prod., 2005, 68, 108-111.
Bhattacharya, G.; Gerena, L.; Jiang, S.; Werbovetz, K. Activity of amidine-containing diphenylureas against P. falciparum, Lett. Drug Design Discov., 2005, 2, 162-164.
Bhattacharya, G.; Herman, J.; Delfin, D.; Salem, M.; Barszcz, T.; Mollet, M.; Riccio, G.; Brun, R.; Werbovetz, K. Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania, J. Med. Chem., 2004, 47, 1823-1832.
Cottrell, D.; Capers, J.; Salem, M.; DeLuca-Fradley, K.; Croft, S.; Werbovetz, K. Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles, Bioorg. Med. Chem., 2004, 12, 2815-2824.
Arafa, R.; Brun, R.; Werbovetz, K.; Tanious, F.; Wilson, W.; Boykin; D. Synthesis of dicationic 2,5-diarylpyrroles. Heterocyclic Commun., 2004, 10, 423-428.
Jiang, D.; Werbovetz, K.; Varadhachary, A.; Cole, R.; Englund, P. Purification and identification of a fatty acyl-CoA synthetase from Trypanosoma brucei, Mol. Biochem. Parasitol., 2004, 135, 149-152.
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