Larry W. Robertson, PhD

430 Parks Hall
500 West 12th Avenue
Columbus, OH 43210

E-mail: robertson.9@osu.edu

Phone: (614) 292-1423

Education

• PhD Medicinal Chemistry & Pharmacognosy 1971, Purdue University.
• BS Pharmacy 1966, University of Houston.

Areas of Interest

Natural Products

Research involves the production, analysis, isolation and structure elucidation of natural products from microorganisms and higher plants. Our group is involved with studies of biocatalysis of drugs by microorganisms, especially as it relates to mammalian drug metabolism. Current projects include isolation and identification of novel antifungal agents and production of metabolites of antimalarial agents by chemical and microbial transformation.

Selected Publications

• P. Yaipakdee and L.W. Robertson, "Enzymatic Halogenation of Flavanones and Flavones," Phytochemistry 57, 341-347 (2001).

  D.A. Hartman, J.B. Basil, L.W. Robertson and R.W. Curley, "Microbial Biotransformation of Retinoic Acid by Cunninghamella eehinulata and Cunninghamella blakesleeima," Pharmaceutical Res. 7, 270-273 (1990).

  R.E. Shomo, II, A. Chandrasekaran, A.G. Marshall, R.H. Reuning, and L.W. Robertson, "Laser Desorption, Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Digoxin, Digitoxin and their reduced and Sugar-Hydrolyzed Metabolites," Biomed., Environ. Mass Spectrom. 15, 947-953 (1988).

  A. Chandrasekaran, L.W. Robertson, and R.H. Reuning, "Reductive Inactivation of Digitoxin by Cultures of Eubacterium lentum," Appl. Environ. Microbiol. 53, 901-904 (1987).

  R.H. McClanahan and L.W. Robertson, "Biotransformation of Olivetol by Syncephalastrum racemosum," J. Nat. Prod. 47 (5), 828-834 (1984).

  L.W. Robertson, S.-W. Koh, S.H. Huff, R.K. Malhotra and A. Ghosh, "Microbiological Oxidation of the Pentyl Side Chain of Cannabinoids," Experientia 34 (8), 1020-1022 (1978).

  A.M. Clark, C.D. Hufford and L.W. Robertson, "Two Metabolites from Aspergillus flavipes," Lloydia 40 (2), 146-151 (1977).

Courses Taught

• Pharmacy 710 and 711 ("Pharmaceutical Biotechnology I and 2").

• Pharmacy 851 ("Advanced Pharmacognosy", invited lectures).