Dr. Kinghorn is a Highly Cited Researcher. View his ISI entry at the Highly Cited web site.

Recent Publications (since 2001)

Lee, D.; Park, E.J.; Cuendet, M.; Axelrod, F.; Chavez, P.I.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata,” Bioorganic and Medicinal Chemistry Letters, 11, 1565-1568 (2001). (Invited contribution to a special issue on medicinal chemistry).

Mi, Q.; Cui, B.; Silva, G.L.; Lantvit, D.; Lim, E.; Chai, H.; You, M.; Hollingshead, M.G.; Mayo, J.G.; Kinghorn, A.D.; Pezzuto, J.M. “Pervilleine A, a novel tropane alkaloid that reverses the multidrug resistance phenotype,” Cancer Research, 61, 4030-4037 (2001).

Chávez, D.; Chai, H.-B.; Chagwedera, T.E.; Gao, Q.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Kinghorn, A.D. “Novel stilbenes isolated from the root bark of Ekebergia benguelensis,” Tetrahedron Letters, 42, 3685-3688 (2001).

Lee, D.; Cuendet, M.; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata,” Organic Letters, 3, 2169-2171 (2001).

Lee, D.; Cuendet, M.; Axelrod, F.; Chavez, P.I.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Novel 29-nor-3,4-seco-cycloartane triterpene methyl esters from the aerial parts of Antirhea acutata,” Tetrahedron, 57, 7107-7112 (2001).

Lee, D.; Bhat, K.P.L.; Fong, H.H.S.; Farnsworth, N.R.; Pezzuto, J.M.; Kinghorn, A.D. “Aromatase inhibitors from Broussonetia papyrifera,” Journal of Natural Products, 64, 1286-1293 (2001).

Silva, G.L.; Cui, B.; Chávez, D.; You, M.; Chai, H.-B.; Rasoanaivo, P.; Lynn, S.M.; O’Neill, M.J.; Lewis, J.A.; Besterman, J.L.; Monks, A.; Farnsworth, N.R.; Cordell, G.A.; J.M. Pezzuto, J.M.; Kinghorn, A.D. “Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei,” Journal of Natural Products, 64, 1514-1520 (2001).

Chadwick, L.R.; Wu, C.D.; Kinghorn, A.D. “Isolation of alkaloids from Goldenseal (Hydrastis canadensis rhizomes) using pH zone-refining countercurrent chromatography,” Journal of Liquid Chromatography and Related Technologies, 24, 2445-2453 (2001).

Waffo-Téguo, P.; Hawthorne, M.E.; Cuendet, M.; Mérillon, J.-M.; Kinghorn, A.D.; Pezzuto, J.M.; Mehta, R.G. “Potential cancer chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures,” Nutrition and Cancer, 40, 173-179 (2001).

Kinghorn, A.D. “Pharmacognosy in the 21st century,” Journal of Pharmacy and Pharmacology, 53, 135-148 (2001). (Review article).

Su, B.-N.; Cuendet, M.; Hawthorne, M.E.; Kardono, L.B.S.; Riswan, S.; Fong, H.H.S.; Mehta, R.G.; Pezzuto, J.M.; Kinghorn, A.D. “Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity,” Journal of Natural Products, 65, 163-169 (2002).

Seo, E.-K.; Kim, N.-C.; Wani, M.C.; Wall, M.E.; Navarro, H.A.; Burgess, J.P.; Kawanishi, K.; Kardono, L.B.S.; Riswan, S.; Rose, W.C.; Fairchild, C.R.; Farnsworth, N.R.; Kinghorn, A.D. “Cytotoxic prenylated xanthones and the unusual compounds, anthraquinobenzophenones, from Cratoxylum sumatranum,” Journal of Natural Products, 65, 299-305 (2002).

Su, B.-N.; Misico, R.; Park, E.J.; Santarsiero, B.D.; Mesecar, A.D.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica,” Tetrahedron, 58, 3453-3466 (2002).

Mi, Q.; Cui, B.; Silva, G.L.; Lantvit, D.; Lim, E.; Chai, H.; Hollingshead, M.G.; Mayo, J.G; Kinghorn, A.D.; Pezzuto, J.M. “Pervilleines B and C, new tropane alkaloid aromatic esters that reverse the multidrug resistance in the hollow fiber assay,” Cancer Letters, 184, 13-20 (2002).

Su, B.-N.; Park, E.J.; Mbwambo, Z.H.; Santarsiero, B.D.; Mesecar, A.D.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes,” Journal of Natural Products, 65, 1278-1282 (2002).

Jang, D.S.; Park, E.J.; Hawthorne, M.E.; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; Santarsiero, B.D.; Mesecar, A.D.; Mehta, R.G.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase,” Journal of Agricultural and Food Chemistry, 50, 6330-6334 (2002).

Su, B.-N.; Cuendet, M.; Farnsworth, N.R.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay,” Planta Medica, 68, 1125-1128 (2002).

Kinghorn, A.D.; Soejarto, D.D. “Discovery of terpenoid and phenolic sweeteners from plants,” Pure and Applied Chemistry, 74, 1169-1179 (2002). (Review article).

Kinghorn, A.D., Ed. Stevia: the Genus Stevia, Medicinal and Aromatic Plants – Industrial Profiles Series, vol. 19; Taylor & Francis: London, pp. xii + 211 (2002). (Edited volume).

Kinghorn, A.D. “Overview”; In Stevia: the Genus Stevia, Medicinal and Aromatic Plants – Industrial Profiles Series, vol. 19; Ed. Kinghorn, A.D.; Taylor & Francis: London, pp. 10-17 (2002). (Book chapter).

Kim, N.-C.; Kinghorn, A.D. “Sweet-tasting and sweetness-modifying constituents of plants”; In Studies in Natural Products Chemistry, vol. 27, Bioactive Natural Products (Part H); Ed. Atta-ur-Rahman; Elsevier Scientific Publishers: Amsterdam; pp. 3-57 (2002). (Book chapter).

Su, B.-N., Park, E.J.; Nikolic, D.; Santarsiero, B.D.; Mesecar, A.D.; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; van Breemen, R.B.; Fong, H.H.S.; Farnsworth, N.R.; Pezzuto, J.M.; Kinghorn, A.D. “Activity-guided fractionation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity,” Journal of Organic Chemistry, 68, 2350-2361 (2003).

Jang, D.S.; Park, E.J.; Hawthorne, M.E; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; Santarsiero, B.D.; Mesecar, A.D.; Fong, H.H.S.; Mehta, R.G.; Pezzuto, J.M.; Kinghorn, A.D. “Potential cancer chemopreventive agents from the seeds of Dipteryx odorata (Tonka bean),” Journal of Natural Products, 66, 583-587 (2003).

Su, B.-N.; Park, E.J.; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; Fong, H.H.S., Pezzuto, J.M.; Kinghorn, A.D. “Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay,” Phytochemistry, 63, 335-341 (2003).

Gu, J.-Q.; Li, W.; Kang, Y.-H.; Su, B.-N.; Fong, H.H.S.; van Breemen, R.B.; Pezzuto, J.M.; Kinghorn, A.D. “Minor withanolides from Physalis philadelphica: Structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts,” Chemical and Pharmaceutical Bulletin, 51, 530-539 (2003).

Díaz, F.; Chávez, D.; Lee, D.; Mi, Q.; Chai, H.-B.; Tan, G.T.; Kardono, L.B.S.; Riswan, S.; Fairchild, C.R.; Wild, R.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Kinghorn, A.D. “Cytotoxic analogs of the flavone, vitexicarpin, a constituent of the leaves of Vitex negundo,” Journal of Natural Products, 66, 865-867 (2003).

Su, B.-N.; Kang, Y.-H.; Pinos, R.E.; Santarsiero, B.D.; Mesecar, A.D.; Soejarto, D.D.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Cousseria brevicaulis,” Phytochemistry, 64, 293-302 (2003). (Memorial issue for Prof. J.B. Harborne, FRS).

Hwang, B.Y.; Roberts, S.K.; Chadwick, L.C.; Wu, C.D.; Kinghorn, A.D. “Antimicrobial constituents from Goldenseal (rhizomes of Hydrastis canadensis) against selected oral pathogens,” Planta Medica, 69, 623-627 (2003).

Mi, Q.; Cui, B.; Lantvit, D.; Reyes-Lim, E.; Chai, H.; Pezzuto, J.M.; Kinghorn, A.D.; Swanson, S.M. “Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug-resistance,” Anticancer Research, 23, 3603-3616 (2003).

Kinghorn, A.D. ; Su, B.-N.; Gu, J.-Q.,; Lee, D.; Pezzuto, J.M. “Cancer chemopreventive agents discovered by activity-guided fractionation: an update,” Current Organic Chemistry, 7, 213-226 (2003). (Review article).

Kinghorn, A.D., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Swanson, S.M., Pezzuto, J.M., Wani, M.C., Wall, M.E., Oberlies, N.H., Kroll, D.J., Kramer, R.A., Rose, W.C., Vite, G.D., Fairchild, C.R., Peterson, R.W., Wild, R. “Novel strategies for the discovery of plant-derived anticancer agents,” Pharmaceutical Biology, 41 (Supplement), 53-67 (2003). (Review article).

Kinghorn, A.D.; Chávez, D. “Pharmaceuticals, plant drugs”; In Encyclopedia of Applied Plant Sciences; Eds. Thomas, B., Murphy, D.J., Murray, B.G.; Academic Press: London, pp. 1145-1152 (2003). (Book chapter).

Jang, D.S.; Cuendet, M.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2,” Journal of Agricultural and Food Chemistry, 52, 2218-2222 (2004).

Ito, A.; Chai, H.-B.; Kardono, L.B.S.; Setowati, F.M.; Afriastini, J.J.; Riswan, S.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Swanson, S.M.; Kinghorn, A.D. “Saponins from the bark of Nephelium maingayi,” Journal of Natural Products, 67, 201-205 (2004). (Issue dedicated to the late Dr. Monroe E. Wall and to Dr. Mansukh C. Wani).

Rivero-Cruz, J.F.; Chai, H.-B.; Kardono, L.B.S.; Setyowai, F.M.; Afriatini, J.J.; Riswan, S.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Swanson, S.M.; Kinghorn, A.D. “Cytotoxic constituents from the twigs of Aglaia rubiginosa,” Journal of Natural Products, 67, 343-347 (2004).

Díaz, F.; Chai, H.-B.; Mi, Q.; Su, B.-N.; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Swanson, S.M.; Kinghorn, A.D. “Anthrone and oxanthone C-glycosides from Picramnia latifolia,” Journal of Natural Products, 67, 353-356 (2004).

Hwang, B.Y.; Su, B.-N.; Chai, H.; Mi, Q.; Kardono, L.B.S.; Afriastini, J.J.; Riswan, S.; Santarsiero, B.D.; Mesecar, A.D.; Fairchild, C.R.; Wild, R.; Vite, G.D.; Rose, W.C.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Swanson, S.M.; Kinghorn, A.D. “Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris,” Journal of Organic Chemistry, 69, 3350-3358 and 6156 (2004).

Jang, D.S.; Park, E.J.; Kang, Y.-H.; Schunke Vigo, J.; Graham, J.G.; Carbieses, F.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Phenolic compounds obtained from the stems of Coepia ulei with the potential to induce quinone reductase,” Archives of Pharmacal Research, 27, 169-172 (2004).

Shin, Y.C.; Udeani, G.O. Kosemeder II, J.W.; Zhao, G.-M.; Dagaar, S.; Onyuksel, H.; Moriarty, R.M.; Cordell, G.A.; Moon, R.C.; Kinghorn, A.D.; Pezzuto, J.M. “Identification of a degradation product of deguelin and its stability using liquid chromatography and electrospray mass spectrometry,” Journal of Liquid Chromatography and Related Technologies, 27, 1057-1069 (2004).

Braca, A.; Armonise, A.; Morelli, I.; Mendez, J.; Mi, Q.; Chai, H.-B.; Swanson, S.M.; Kinghorn, A.D.; De Tomassi, N. “Structures of ent-kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity,” Planta Medica,70, 540-550 (2004).

Gu, J.-Q.; Graf, T.N.; Lee, D.; Chai, H.-B.; Kardono, L.B.S.; Setyowati, F.M.; Ismail, R.; Riswan, S.; Farnsworth, N.R.; Cordell, G.A.; Pezzuto, J.M.; Swanson, S.M.; Kroll, D.J.; Falkingham III, J.O.; Wall, M.E.; Wani, M.C.; Kinghorn, A.D.; Oberlies, N.H. “Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia,” Journal of Natural Products, 67, 1156-1161 (2004).

Jang, D.S.; Cuendet, M.; Su, B.-N.; Totura, S.; Riswan, S.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2,” Planta Medica, 70, 893-896 (2004). (Issue dedicated to Prof. Dr. A. Nahrstedt on his retirement as Editor-in-Chief of Planta Medica).

Su, B.-N.; Jones, W.P.; Cuendet, M.; Kardono, L.B.S.; Ismail, R.; Riswan, S.; Fong, H.H.S.; Farnsworth, N.R.; Pezzuto, J.M.; Kinghorn, A.D. “Constituents of the stems of Macrococculus pomiferus and their inhibitory activities on cyclooxygenases-1 and -2,” Phytochemistry, 65, 2861-2866 (2004). (Issue in honor of the 60th birthday of Prof. K. Hostettmann).

Su, B.-N.; Hwang, B.Y.; Chai, H.; Carcarche-Blanco, E.J.; Kardono, L.B.S.; Afriastini, J.J.; Riswan, S.; Wild, R.; Laing, N.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Kinghorn, A.D. “Activity-guided fractionation of the leaves of Ormosia sumatrana using a proteasome inhibition assay,” Journal of Natural Products, 67, 1911-1914 (2004).

Su, B.-N.; Gu, J.-Q.; Kang, Y.-H.; Park, E.J.; Pezzuto, J.M.; Kinghorn, A.D. “Induction of the phase II enzyme, quinone reductase, by withanolides and norwithanolides from Solanaceous species,” Mini Reviews in Organic Chemistry, 1, 115-123 (2004). (Review article).

Kinghorn, A.D. ; Su, B.-N.; Jang, D.S.; Jang, D.S.; Chang, L.C.; Lee, D.; Gu, J.-Q.; Carcache-Blanco, E.J.; Pawlus, A.D.; Lee, S.K.; Park, E.J.; Cuendet, M.; Gills, J.J.; Bhat, K.; Park, H.-S.; Mata-Greenwood, E.; Song, L.L.; Jang, M.; Pezzuto, J.M. “Natural inhibitors of carcinogenesis,” Planta Medica, 70, 691-705 (2004). (Review article)

Kinghorn, A.D. ; Pezzuto, J.M.; Lee, D.; Bhat, K.P.L. “Aromatase inhibitors from Brossonetia papyrifera,” U.S. patent, serial number 6,737,439 B2, May 18, 2004, 34 pp.

Rivero-Cruz, J.F., Lezutekong, R., Lobo-Echeverri, T., Ito, A., Mi, Q., Chai, H.-B., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Morelli, I., Kinghorn, A.D. “Cytotoxic constituents of the twigs of Simaruba glauca,” Phytotherapy Research, 19, 136-140 (2005).

Lobo-Echeverri, T., Rivero-Cruz, J.F., Su, B.-N., Chai, H.-B., Cordell, G.A., Pezzuto, J.M., Swanson, S.M., Soejarto, D.D., Kinghorn, A.D. “Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in southern Florida,” Journal of Natural Products, 68, 577-580 (2005).

Su, B.-N., Pawlus, A.D., Jung, H.-A., Keller, W.J., McLaughlin, J.L., Kinghorn, A.D. “Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity,” Journal of Natural Products, 68, 592-595 (2005).  

Mi, Q., Lantvit, D., Reyes-Lim, E., Chai, H., Phifer, S.S., Wani, M.C., Wall, M.E., Tan, G.T., Cordell, G.A., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M. “Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitensis,” Anticancer Research, 25, 779-788 (2005).  

Jang, D.S., Su, B.-N., Pawlus, A.D., Jones, W.P., Kleps, R.A., Bunyapraphatsara, N., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D., “Limnophilospiroketone, a highly oxygenated phenolic derivative from Limnophila goeffrayi,” Journal of Natural Products, 68, 1134-1136 (2005).  

Jones W.P.; Lobo-Echeverri, T; Mi, Q.; Chai, H.; Lee, D.; Soejarto, D.D.; Cordell, G.A.; Pezzuto, J.M.; Swanson, S.M.; Kinghorn, A.D. “Antitumor activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida,” Journal of Pharmacy and Pharmacology, 57, 1101-1108 (2005). (Invited contribution to a special issue on medicinal plants of neotropical origin).

Lee, D.; Li, C.; Graf, T.N.; Schunke Vigo, J.; Graham, J.G.; Cabieses, F.; Farnsworth, N.R.; Cordell, G.A.; Kinghorn, A.D.; Kroll, D.J.; Wani, M.C.; Oberlies, N.H. “Diterpene glycosides from Egletes viscosa,” Planta Medica, 71, 792-794 (2005).

Kim, S.; Su, B.-N.; Riswan, S.; Kardono, L.B.S.; Afriastini, J.J.; Gallucci, J.C.; Chai, H.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Kinghorn, A.D. “Edulisones A and B, two epimeric benzo[b]oxepine derivatives from the bark of Aglaia edulis,” Tetrahedron Letters, 46, 9021-9024 (2005).

Li, C.; Lee, D.; Graf, T.N.; Phifer, S.S.; Nakanishi, Y.; Burgess, J.P.; Riswan, S. Setyowati, F.M.; Saribi, A.M.; Soejarto, D.D.; Farnsworth, N.R.; Falkinham III, J.O.; Kroll, D.J.; Kinghorn, A.D.; Wani, M.C.; Oberlies, N.H. “A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra,” Organic Letters, 7, 5709-5712 (2005).

Balunas, M.J.; Kinghorn, A.D. “Drug discovery from medicinal plants,” Life Sciences, 78, 431-441 (2005). (Invited review).

Pezzuto, J.M., Kosmeder II, J.W., Park, E.J., Lee, S.K., Cuendet, M., Gills, J., Bhat, K., Grubjesic, S., Park, H.-S., Mata-Greenwood, E., Tan, Y., Yu, R., Lantvit, D.D., Kinghorn, A.D. “Characterization of natural product cancer chemopreventive agents”; In Cancer Chemoprevention. Vol. 2. Strategies for Cancer Chemoprevention; Eds. Kelloff, G.J., Hawk, E.T., Sigman, C.C.; Humana Press, Totowa, NJ, pp. 3-37 (2005).

 Gu, J.-Q.; Kinghorn, A.D. “Bioactive constituents of the genus Hernandia”; In Studies in Natural Products Chemistry, vol. 30, Bioactive Natural Products (Part K); Ed. Atta-ur-Rahman; Elsevier Scientific Publishers: Amsterdam; pp. 559-602 (2005). (Book chapter).

Jones, W.P.; Kinghorn, A.D. “Extraction of plant secondary metabolites”; In Natural Products Isolation, 2 nd Edn. (Methods of Biotechnology Series, No. 20), Eds. Sarker, S.D., Latif, Z., Gray, A.I., Humana Press: Totowa, NJ, 2005, pp. 323-351. (Invited book chapter)

Pawlus, A. D.; Su, B.-N.; Kinghorn, A.D. “Noni (Morinda citrifolia L.)”; In The Encyclopedia of Dietary Supplements; Eds. Coates, P. M., Blackman, M. R., Cragg, G. M., Levine, M., Moss, M., White J. D.; Marcel Dekker: New York, pp. E1-E8. (2005) (Book chapter; published electronically).

Su, B.-N.; Mi, Q.; Chai, H.; Riswan, S.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Kinghorn, A.D. “Activity-guided isolation of cytotoxic glabretal triterpenoids from Aglaia crassinervia,” Bioorganic and Medicinal Chemistry, 14, 960-972 (2006).

Fang, L.; Ito, A.; Chai, H.-B.; Mi, Q.; Jones, W.P.; Madulid, D.R.; Oliveros, M.B.; Gao, Q.; Orjala, J.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Kinghorn, A.D. “Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines,” Journal of Natural Products, 69, 332-337 (2006). (In issue dedicated to Professor Norman R. Farnsworth).

Chin, Y.-W.; Jones, W.P.; Waybright, T.J.; McCloud, T.G.; Rasoanaivo, P.; Cragg, G.M., Cassady, J.M.; Kinghorn, A.D. “Tropane aromatic ester alkaloids from a large-scale recollection of Erythroxylum pervillei stem bark obtained in Madagascar,” Journal of Natural Products, 69, 414-417 (2006). (In issue dedicated to Professor Norman R. Farnsworth).

Chin, Y.-W., Jones, W.P.; Rachman, I.; Riswan, S.; Kardono, L.B.S.; Chai, H.-B.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Cassady, J.M.; Kinghorn, A.D. “Cytotoxic lignans from the stems of Helicteres hirsuta collected in Indonesia,” Phytotherapy Research, 20, 62-65 (2006).

Jung, H.-A.; Su, B.-N.; Keller, W.J.; Mehta, R.G.; Kinghorn, A.D. “Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen),” Journal of Agricultural and Food Chemistry, 54, 2077-2082 (2006).

Carcache-Blanco, E.J.; Cuendet, M.; Park, E.J.; Su, B.-N.; Rivero-Cruz, J.F.; Farnsworth, N.R.; Pezzuto, J.M.; Kinghorn, A.D. “Potential cancer chemopreventive agents from Arbutus unedo,” Natural Products Research. Part B. Biologically Active Natural Products, 20, 327-334 (2006).

Balunas, M.J.; Su, B.; Landini, S.; Brueggemeier, R.W.; Kinghorn, A.D. “Interference by naturally occurring fatty acids in a non-cellular enzyme-based aromatase bioassay.” Journal of Natural Products, 69, 700-703 (2006).

Mi, Q.; Su, B.-N.; Chai, H.; Farnsworth, N.R.; Kinghorn, A.D.; Swanson, S.M. “Rocaglaol induces apoptosis and cell-cycle arrest in LNCaP cells,” Anticancer Research, 26 (2A), 947-952 (2006).

Chin, Y.-W.; Jones, W.P.; Mi, Q.; Rachman.; Riswan, S.; Kardono, L.B.S.; Chai, H.-B.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Cassady, J.M.; Kinghorn, A.D. “Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa,” Phytochemistry, 67, 1243-1248 (2006).

Jang, D.S.; Su, B.-N.; Pawlus, A.D.; Kang-Y.-H.; Riswan, S.; Afriastini, J.J.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. “Beccaridiol, a 28-nortriterpenoid from the leaves of Diplectria beccariana,” Phytochemistry, 67, 1832-1837 (2006). (Special issue in honor of Professor Rodney B. Croteau).

Balunas, M.J.; Jones, W.P.; Chin, Y.-W.; Mi, Q.; Farnsworth, N.R.; Soejarto, D.D.; Cordell, G.A.; Swanson, S.M.; Pezzuto, J.M.; Chai, H.-B.; Kinghorn, A.D. “Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project,” Chemistry & Biodiversity, 3, 897-915 (2006).

Kinghorn, A.D.; Pezzuto, J.M.; Silva, G.L.; Cui, B.; You, M. “Tropane alkaloid multidrug resistance inhibitors from Erythroxylum pervillei and uses of the same,” U.S. Patent 6,986,396 B2, January 24, 2006, 44 pp.

Jones, W.P.; Chin, Y.-W; Kinghorn, A.D. “The role of pharmacognosy in modern medicine and pharmacy,” Current Drug Targets, 7, 247-264 (2006). (Review article).
Chin, Y.-W.; Balunas, M. J; Chai, H.-B.; Kinghorn, A.D. “Drug discovery from natural sources,” AAPS Journal, #8 (2), article #28, E239-E253 (2006). (Review article; published electronically).

Kim, S.; Salim, A.; Swanson, S.M.; Kinghorn, A.D. “Potential of cyclopenta[b]-benzofurans from Aglaia species in cancer chemotherapy,” Anti-cancer Agents in Medicinal Chemistry (formerly Current Medicinal Chemistry – Anti-cancer Agents), 6, 318-345 (2006). (Review article).

Kinghorn, A.D.; Kim, N.-C. “Discovering new natural sweeteners”; In Optimising Sweet Taste in Foods; Ed. W.J. Spillane; Woodhead Publishing Co./CRC Press: Cambridge, U.K., 2006; pp. 292-306. (Book chapter).

Salim, A.A.; Pawlus, A.D.; Chai, H.-B.; Farnsworth, N.R.; Kinghorn, A.D.; Carcache-Blanco, E.J. “Ponapensin, a cyclopenta[b,c]benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis,” Bioorganic and Medicinal Chemistry Letters, 17, 109-112 (2007).

Jones, W.P.; Lobo-Echeverri, T.; Mi, Q.; Chai, H.-B.; Soejarto, D.D.; Cordell, G.A.; Swanson, S.M.; Kinghorn, A.D. “Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida,” Journal of Natural Products, 70, 372-377 (2007). (Special issue dedicated to the late Dr. Kenneth L. Rinehart).

Murillo, G.; Hirschelman, W.H.; Ito, A.; Moriarty, R.M.; Kinghorn, A.D.; Pezzuto, J.M.; Mehta, R.G. “Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis,” Nutrition and Cancer, 57, 28-37 (2007).

Salim, A.A.; Su, B.-N.; Chai, H.-B.; Riswan, S.; Kardono, L.B.S.; Ruskardi, A.; Farnsworth, N.R.; Swanson, S.M.; Kinghorn, A.D. “Dioxodispiroketal compounds and a potential acyclic precursor from Amomum aculeatum,” Tetrahedron Letters, 48, 1849-1853 (2007).

Chin, Y.-W.; Jung, H.-A.; Su, B.-N.; Liu, Y.; Castoro, J.A.; Keller, W.J.; Pereira, M.A.; Kinghorn, A.D. “Anti-oxidant constituents of the roots and stolons of Licorice (Glycyrrhiza glabra).” Journal of Agricultural and Food Chemistry, 55, 4691-4697 (2007).

Phifer, S.S.;  Lee, D.; Seo, E.-K.; Kim, N.-C.; Graf, T.N.; Kroll, D.J.; Navarro, H.A.; Izydone, R.A.; Jiminez, F.; Garcia, R.; Rose, W.C.; Fairchild, C.R.; Wild, R.; Soejarto, D.D.; Farnsworth, N.R.; Kinghorn, A.D.; Oberlies, N.H.; Wall, M.E.; Wani, M.C. “Alvaradoins E-N, new antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitensis,” Journal of Natural Products, 70, 954-961.

Wu, C.D.; Kinghorn, A.D.; Roberts, S.K. “Method and composition for controlling oral pathogens,” U.S. patent application publication, US2007/0098649 A1, May 3, 2007, 22 pp.

Ding, H.; Chin, Y.-W.; Kinghorn, A.D.; D’Ambrosio, S. “Chemopreventive characteristics of avocado fruit,” Seminars in Cancer Biology, 17, 386-394 (2007). (Review article).

Pawlus, A.D.; Kinghorn, A.D. “Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni),” Journal of Pharmacy and  Pharmacology, 59, 1587-1609 (2007). (Review article).

Chin, Y.-W.; Jung, H.A.; Chai, H.; Keller, W.J.; Kinghorn, A.D. “Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen),” Phytochemistry, 69, 754-758 (2008).

Chin, Y.-W.; Salim, A.A.;  Su, B.-N.; Mi, Q.; Chai, H.-B.; Riswan, S.; Kardono, L.B.S.; Ruskandi, A.; Farnsworth, N.R.; Swanson, N.R.; Kinghorn, A.D. “Potential anticancer activity of naturally occurring and semi-synthetic derivatives of aculeatins A and B from Amomum aculeatum,” Journal of  Natural Products, 71, 390-395 (2008). (Special issue in honor of Dr. G. Robert Pettit).

Balunas, M.J; Su, B; Brueggemeier, R.W; Kinghorn, A.D. “Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity,” Journal of Natural Products, 71, 1161-1166 (2008).

Tomosaka, H.; Chin, Y.-W.; Salim, A.A; Keller, W.J.; Chai, H.; Kinghorn, A.D. “Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry),” Phytotherapy Research, 22, 979-981 (2008).

Chin, Y.-W.; Chai, H.-B.; Keller, W.J.; Kinghorn, A.D. “Lignans and other constituents of the fruits of Euterpe oleracea (Açai) with antioxidant and cytoprotective activities,” Journal of Agricultural and  Food Chemistry, 56, 7759-7764 (2008).

Jones, W.P.; Kinghorn, A.D. “Biologically active compounds from the genus Callicarpa,” Current Bioactive Compounds 4, 15-32. (2008). (Review article).

Balunas, M.J.; Su, B.; Brueggemeier, R.W.; Kinghorn, A.D. “Natural products as aromatase inhibitors,” Anti-cancer Agents in Medicinal Chemistry, 8, 646-682 (2008). (Review article).

Chin, Y.-W.; Kinghorn, A.D. “Structural characterization, biological effects, and synthetic studies on xanthones from the fruits of mangosteen (Garcinia mangostana), a popular dietary supplement,” Mini-Reviews in Organic Chemistry, 5, 355-364 (2008). (Review article).

Kinghorn, A.D. “Drug discovery from natural products”; In Foye’s Principles of Medicinal Chemistry, Sixth Edition; Eds. Lemke, T., Williams, D.A.; Walters Kluwer/Lippincott Willliams & Wilkins, Baltimore, MD, 2008; pp. 12-25. (Textbook chapter).

Bahar, M.; Deng, Y.; Fletcher, J.N.; Kinghorn, A.D. “Plant-derived natural products in drug discovery and development: an overview”;  In Selected Topics in the Chemistry of Natural Products; Ed. Ikan, R.; World Scientific Publications, Singapore, 2008; pp. 11-48. (Book chapter).

Salim, A.A.; Chin, Y.-W.; Kinghorn, A.D. “Drug discovery from plants”; In Bioactive Molecules and Medicinal Plants; Eds. Ramawat, K., Merillon, J.-M.; Springer-Verlag: Berlin and Heidelberg, 2008; pp. 1-24. (Book chapter).

Chin, Y.-W.; Balunas, M.J.; Chai, H.-B; Kinghorn, A.D. “Drug discovery from natural sources”; in Drug Addiction: from Basic Research to Therapy; Eds. R.S. Rapaka and W. Sadee, Springer-AAPS Press, New York, 2008; pp. 17-39. [Republication of an electronic review article (AAPS J, 8(2), article #28, E239-E253, 2006)].

Chin, Y.W.; Kinghorn, A.D. “Natural products”; in Encyclopedia of Cancer, 2nd Edn.; Ed. M. Schwab; Springer: Berlin and Heidelberg, 2008; Part 14 (N), pp. 2032-2034.

Kinghorn, A.D.; Falk, H.; Kobayashi, J., Series Editors. Progress in the Chemistry of Organic Natural Products (Fortschritte de Chemie organischer Naturstoffe), vol. 89; Springer-Verlag: Vienna, Austria, 2008, 163 pp. (Co-edited volume).

Pan, L.; Sinden, M.; Kennedy, A.H.; Chai, H.; Watson, L.E.; Graham, T.; Kinghorn, A.D. “Bioactive constituents of Helianthus annuus (Jerusalem artichoke),” Phytochemistry Letters, 2, 15-18 (2009).

Balunas, M.J.; Su, B; Riswan, S.; Fong, H.H. S.; Brueggemeier, R.W.; Pezzuto, J.M.; Kinghorn, A.D. “Isolation and characterization of aromatase inhibitors from Brassaiopsis glomerulata (Arialaceae),” Phytochemistry Letters, 2, 29-33 (2009).

Pan, L.; Chin, Y.-W.; Chai, H.-B.; Ninh, T. N.; D.D. Soejarto, D.D.; Kinghorn, A.D. “Activity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam,” Bioorganic and Medicinal Chemistry, 17, 2219-2224 (2009). (In “Symposium in Print” entitled “Natural Products in Medicinal Chemistry”, Guest Editors G.M. Cragg and D.J. Newman).

Ding, H.; Han, C.; Guo, D.; Chin, Y.-W.; Ding, Y.; Kinghorn, A.D.; D’Ambrosio, S.M. “Selective induction of apoptosis of human oral cancer cell lines by avocado extracts via a ROS-mediated mechanism,” Nutrition and Cancer, 61, 348-356 (2009).

Lucas, D.M.; Edwards, R.B.; Lozanski, G.; West, D.A.; Shin, J.D.; Vargo, M.A.; Davis, M.E.; Rozewski, D.M.; Johnson, A.J.; Su, B.-N.; Goettl, V.M.; Lin, T.S.; Lehman, A.; Zhang, X.; Jarjoura, D.; Newman, D.J.; Byrd, J.C.; Kinghorn, A.D; Grever, M.R. “The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo,” Blood, 113, 4656-4666 (2009).

Kinghorn, A.D.; Chin, Y.W.; Swanson, S.M. “Discovery of natural product anticancer agents from biodiverse organisms,” Current Opinion in Drug Discovery and Development, 12, 189-196 (2009). (Review article).

Mi, Q.; J.M. Pezzuto, J.M.; Farnsworth, N.R.; Wani, M.C.; Kinghorn, A.D.; Swanson, S.M. “Use of the in vivo hollow fiber assay in natural products drug discovery.” Journal of Natural Products, 72, 573-580 (2009). (Special issue in honor of Dr. David G. Kingston; review article).

Kinghorn, A.D.; Carcache-Blanco, E.J.; Chai, H.-B.; Orjala, J.; Farnsworth, N.R.; Soejarto, D.D.; Oberlies, N.H.; Wani, M.C.; Kroll, D.J.;  Pearce, C.J.; Swanson, S.M.; Kramer, R.A.; Rose, W.C.; Emanuel, S.;  Vite, G.D.; Jarjoura, J.; Cope, F.O. “Discovery of anticancer agents of diverse natural origin”, Pure and Applied Chemistry, 81, 1051-1063 (2009). (Review article).

Doskotch, R.W.; Robertson, L.W.; Patil, P.N.; Kinghorn, A.D. “The Ohio State University: History of pharmacognosy and natural products in a nutshell”; In The American Society of Pharmacognosy: 50 Years of Progress in Natural Products Research, 1959-2009; Eds. Cragg, G.M.; Beutler, J.B.; Jones, W.P.; American Society of Pharmacognosy: Northbrook, IL, 2009; pp. 109-111. (Book chapter).

Kinghorn, A.D. “History of Lloydia and the Journal of Natural Products”;In The American Society of Pharmacognosy: 50 Years of Progress in Natural Products Research, 1959-2009 Eds. Cragg, G.M.; Beutler, J.B.; Jones, W.P.; American Society of Pharmacognosy: Northbrook, IL, 2009; pp. 259-266. (Book chapter).

Kinghorn, A.D.; Falk, H.; Kobayashi, J., Series Editors. Progress in the Chemistry of Organic Natural Products; vol. 90. Springer-Verlag: Vienna, Austria, 2009; 260 pp. (Co-edited Volume entitled “The Epothilones: An Outstanding Family of Anti-Tumor Agents. From Soil to the Clinic”; Authors: Altmann; K.-H.; Höfle, G.; Müller, R.; Mulzer, J.; Prantz, K.).

Balunas, M.J.; Su, S.; Brueggemeier, R.W.; Kinghorn, A.D. “Compositions from Garcinia as aromatase inhibitors for breast cancer chemoprevention and chemotherapy”, PCT International Application WO 2009011811 A1, January 22, 2009.

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