Robert W. Curley, Jr., PhD
Selected Publications
Inhibition of Mammary Tumor Growth by a Novel Nontoxic Retinoid: Chemotherapeutic Evaluation of a C-linked Analog of 4-HPR-Glucuronide. Alshafie, G.A.; Walker, J.R.; Curley, R.W. Jr.; Clagett-Dame, M.;
Highland, M.A.; Nieves, N.J.; Stonerock, L.A.; Abou-Issa, H. Anticancer Res. 2005, 25, 2391-2398.
Identification of the Fenretinide Metabolite 4-Oxo-Fenretinide Present in Human Plasma and formed in Human Ovarian Carcinoma Cells through CYP26A1 Induction. Villani, M.G.; Appierto, V.; Cavadini, E.; Valsecchi, M.; Sonnino, S.; Curley, R.W. Jr.; Formelli, F. Clin. Cancer Res. 2004, 10, 6265-6275.
Hydrolysis of 4-HPR to atRA Occurs In Vivo but is not Required for Retinamide-Induced Apoptosis. Chapman, J.S.; Weiss, K.L.; Curley, R.W. Jr.; Highland, M.A.; Clagett-Dame, M. Arch. Biochem. Bio phys. 2003, 419, 234-243.
Stereoselective Route to 15N-Labeled-β-Deuterated Amino Acids: Synthesis of (2S,3R)-[3-2H,15N]-Phenylalanine. Barnett, D.W.; Panigot, M.J.; Curley, R.W. Jr. Tetrahedron: Asymmetry 2002, 13, 1893-1900.
An Improved Synthesis of the C-Linked Glucuronide of N-(4-Hydroxyphenyl)retinamide. Walker, J.R.; Alshafie, G.; Abou-Issa, H.; Curley, R.W., Jr., Bioorg. Med. Chem. Lett. 2002, 12, 2447-2450
Improved Synthesis of (R)-Glycine-d-15N. Walker, J.R.; Curley, R.W., Jr. Tetrahedron 2001, 57, 6695-6701.
Chemotherapeutic Evaluation of 4-Hydroxybenzylretinone (4-HBR), a Nonhydrolyzable C-Linked Analog of N-(4-Hydroxyphenyl)retinamide (4-HPR) Against Mammary Carcinogenesis. Abou-Issa, H.; Curley, R.W., Jr.; Alshafie, G.H.; Weiss, K.L.; Clagett-Dame, M.; Chapman, J.S.; Mershon, S.M. Anticancer Res. 2001, 21, 3839-3844.
An Unhydrolyzable Analog of N-(4-Hydroxyphenyl)retinamide: Synthesis and Preliminary Biological Studies. Weiss, K.L.; Alshafie, G.; Chapman, J.S.; Mershon, S.M.; Abou-Issa, H.; Clagett-Dame, M.; Curley, R.W., Jr. Bioorg. Med. Chem. Lett. 2001, 11,1583-1586.
Virtual Coupling of Pyran Protons in the 1H NMR Spectra of C- and N-Glucuronides: Dependence on Substitution and Solvent. Panigot, M.J.; Robarge, M.J.; Curley, R.W., Jr. AAPS PharmSci 2001, 3 Article 4 (http://www.aapsj.org/view.asp?art=ps030104).
NMR Studies of Retinoid-Protein Interactions: The Conformation of [13C]-β-Ionones Bound to β-Lactoglobulin B. Curley, R.W., Jr.; Sundaram, A.K.; Fowble, J.W.; Abildgaard, F.; Westler, W.M.; Markley, J.L. Pharm. Res. 1999, 16, 651-659.
Synthesis and Receptor Binding Affinity of Conformationally Restricted Retinoic Acid Analogues. Wong, M.F.; Repa, J.J.; Clagett-Dame, M.; Curley, R.W., Jr. Bioorg. Med. Chem. Lett. 1997, 7, 2313-2318.
Chemopreventive Activities of C-Glucuronide/Glycoside Analogs of Retinoid-O-Glucuronides Against Breast Cancer Growth and Development. Curley, R.W., Jr.; Abou-Issa, H.; Panigot, M.J.; Repa, J.J.; Clagett-Dame, M.; Alshafie, G. Anticancer Res. 1996, 16, 757-764.
Preparation of 4-Retinamidophenyl- and 4-Retinamidobenzyl-C-Glycosyl and C-Glucuronosyl Analogues of the Glucuronide of 4-Hydroxyphenylretinamide as Potential Stable Cancer Chemopreventive Agents. Panigot, M.J.; Humphries, K.A.; Curley, R.W., Jr. J. Carbohydr. Chem. 1994, 13, 303-321.
Stereospecific Assignments of Glycine in Proteins by Stereospecific Deuteration and 15N-Labeling. Curley, R.W., Jr.; Panigot, M.J.; Hansen, A.; Fesik, S.W. J. Biomol. NMR 1994, 4, 335-340.
N-Linked Analogs of Retinoid O-Glucuronides: Potential Cancer Chemopreventive/Chemotherapeutic Agents. Robarge, M.J.; Repa, J.J.; Hanson, K.K.; Seth, S.; Clagett-Dame, M.; Abou-Issa, H.; Curley, R.W., Jr. Bioorg. Med. Chem. Lett. 1994, 4, 2117-2122.
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