Medicinal Chemistry and Pharmacognosy Dissertation Topics Archive

Bulbul Pandit, PhD, 2007
Advisor: Dr. Li
Title: Study of Structure Activity Relationship of Analogs Derived from SU-5416 and Thalidomide and Mechanism of Antiproliferative Activity

Zhao Xiaobin, PhD, 2007
Advisor: Dr. Lee
Title: Targeting CD37 and Folate Receptor for Cancer Therapy: Strategies Based On Engineered Protein and Liposomes

Bin Su, PhD, 2006
Advisor: Dr. Brueggemeier
Title: Development of Aromatase Inhibitors and Selective Aromatose Expression Regulators for Hormone Dependent Breast Cancer

Chang-Shi Chen , PhD, 2006
Advisor: Dr. Chen
Title: Beyond Induction of Histone Acetylation: The Multi-facets of the Antineoplastic Effect of Histone Deacetylase Inhibitors

Yating Yang, PhD, 2006
Advisor: Dr. Chen
Title: Molecularly Targeted Therapy for Ovarian Cancer

Youngjoo Byun, PhD, 2006
Advisor: Dr. Tjarks
Title: Thymidine Kinase as a Molecular Target for the Development of Novel Anticancer and Antibiotic Agents

Chung-Wai Shiau, PhD, 2005
Advisor: Chen, Ching-Shih
Title: Thiazolidinediones: from peroxisome-proliferator-activatived receptor r (pparr) to anticancer agents.

Edgar S. Diaz-Cruz, PhD, 2005
Advisor: Brueggemeier, Robert W
Title: Interrelationships between aromatase and cyclooxygenase-2 and their role in the autocrine and paracrine mechanisms in breast cancer

Ho-Pi Lin , PhD, 2005
Advisor: Chen, Ching-Shih
Title: Celecoxib: Its non-cox-2 targets and its anti-cancer effects

Jiuxiang (Julie) Zhu, PhD, 2005
Advisor: Chen, Ching-Shih
Title: From celebrex to a novel class of phosphoinositde-dependent kinase-1 (PDK-1) inhibitors for androgen-independent prostate caner [sic]

Jui-Wen Huang, PhD, 2005
Advisor: Chen, Ching-Shih
Title: Part I: troglitazone analogues as cyclin d1 ablative agents: the potential drugs for breast cancer therapy. Part 2: vitamin E and its analgues thduce apoptosis in prostate cancer cells in part through inhibition.

Keun-Feng Chen, PhD, 2005
Advisor: Chen, Ching-Shih
Title: Troglitazone: from an insulin sensitizer to a novel class of anti-cancer agent.

Manar Salem, Ph.D., 2005
Advisor: Werbovetz, Karl
Title: Identification of antikinetoplastid compounds from Psorothamnus polydenius and P. arborescens.

Ping-Hui Tseng, PhD, 2005
Advisor: Chen, Ching-Shih
Title: PDK-1/ Akt pathway as targets for chemosensitizing effects.

Qiang Lu, PhD, 2005
Advisor: Chen, Ching-Shih
Title: Potent Short-Chain Fatty Acid-based Histone Deacetylare Inhibitors as Anti-tumor Agents

Serena Landini, MS, 2005
Advisor: Brueggemeier, Robert W.
Title: Effects of natural and synthetic flavonoids on molecular targets in breast cancer

Yeng-Jeng Shaw, Ph.D., 2005
Advisor: Chen, Ching-Shih
Title: Small Molecule-based Drug Design of Anticancer Agents that Target Protein Kinase B/ AKT, BCL-xL and DNA Methyltransferases for the Treatment of Prostate Cancer

James E. Cox, PhD, 2004
Advisor: Priestly/Brueggemeier, Robert W
Title: Characterization of NonR, an esterase that confers nonactin resistance

John C Hackett, PhD, 2004
Advisor: Brueggemeier, Robert W
Title: Computational investigations of cytochrome P450 aromatase catalysis and biological evaluation of isoflavone aromatase inhibitors

Joel R. Walker, PhD, 2003
Advisor: Curley, Robert W
Title: Part 1. Synthesis of N-15 labeled (R)-deuterioglycine. Part 2. Synthesis of carbon-Linked analogs of retinoid glycoside conjugates

Young-Woo Kim, PhD, 2003
Advisor: Brueggemeier, Robert W
Title: Novel 2-substituted isoflavones: a privileged structure approach to new agents for hormone-dependent breast cancer

David J. Lapinsky, PhD, 2002
Advisor: Bergmeier/Brueggemeier
Title: Studies in aziridine-allylsilane chemistry

Derek W. Barnett, PhD, 2002
Advisor: Curley, Robert W
Title: Part 1. Synthesis of stable-isotope labeled amino acids. Part 2. Synthesis of mechanistic probes of retinoid action

Jennifer Amy Zink, MS, 2002
Advisor: Li, Pui-Kai
Title: SAR study and mechanism elucidation of thalidomide analogs as anti-proliferative and anti-angiogenic agents

Kristjan M. Arason, PhD, 2002
Advisor: Bergmeier, Stephen C
Title: Analogues of methyllycaconitine (MLA) as antagonists of nicotinic receptors

Jennifer L. Whetstone (Windholtz), PhD, 2001
Advisor: Brueggemeier, Robert W
Title: Identification of synthetic benzopyranones as selective agents for molecular targets in breast cancer

John Allen Means, PhD, 2001
Advisor: Hines/Brueggemeier
Title: Development of assay systems for the study of small molecule interactions with RNA

Jon Howard Baker, Jr., PhD, 2001
Advisor: Brueggemeier, Robert W
Title: Biochemical evaluation of benzopyranones : aromatase inhibition and development of a receptor tyrosine kinase assay

Kevin L. Weiss, PhD, 2001
Advisor: Curley, Robert W
Title: Structural probes of retinoid action

Linda Huong Rakes, MS, 2001
Advisor: Robertson, Larry W
Title: Acid-catalyzed rearrangement products of cinchonine : isolation, antimicrobial and transformation studies

Melinda S. Gerdeman (Xavier), PhD, 2001
Advisor: Brueggemeier, Robert W
Title: Solution structure and in vitro studies of the antiterminator found in Bacillus Subtilis TYRS mRNA

Michael Eric Nelson, PhD, 2001
Advisor: Priestly/Brueggemeier
Title: Nonactin biosynthesis : stable isotope precursor studies

Serena Marie Mershon, MS, 2001
Advisor: Curley, Robert W
Title: Chemical studies of N-(4-Hydroxyphenyl)retinamide and analogs

Surachai (Shaw) Joomprabutra, PhD, 2001
Advisor: Brueggemeier, Robert W
Title: Biological and molecular modeling studies of a benzopyranone library

Abhijit Bhat, PhD, 2000
Advisor: Brueggemeier, Robert W.
Title: Part A: Synthesis and Biochemical Evaluation of Estrogen Metabolite Analogs. Part B: Synthetic Approaches for Constructiong a Benzopyrone Combinatorial Library

James Austin Mobley, PhD, 2000
Advisor: Brueggemeier, Robert W
Title: Oxidative mechanisms of estrogen induced carcinogenesis

Rosario Rojas, PhD, 2000
Advisor: Robertson, Larry W
Title: Secondary metabolites of Vernonia gigantea roots : isolation, antimicrobial, chemical and biotransformation studies

Susan L. Fundy (Donaldson), PhD, 2000
Advisor: Bergmeier, Stephen C
Title: Part 1: synthesis and evaluation of Oligo (5-Aminopentanoic Acid)-Nucleobases : Part 2: studies in Aziridine-Allysilane Chemistry

Punit Seth, PhD, 1999
Advisor: Bergmeier, Stephen C.
Title: Intramolecular cyclization reactions of Aziridines with Allylsilanes, application to total synthesis of (-)-Yohimbane and Ent-Alloyohimbane

Dionne M. Stanchina, PhD, 1998
Advisor: Bergmeier, Stephen C
Title: Acylnitrenes for the synthesis of vicinal amino alcohols : application to the synthesis of (-)-bestatin and analogs

Dionne M. Stanchina, PhD, 1998
Advisor: Bergmeier, Stephen C.
Title: Acylnitrenes for the synthesis of vicinal amino alcohols : application to the synthesis of (-)-bestatin and analogs

Panadda Yaipakdee, PhD, 1998
Advisor: Robertson, Larry W
Title: Secondary metabolites of Aspergillus Candidus : isolation, chemical, antimicrobial and biotransformation studies

Anne L. Quinn, PhD, 1997
Advisor: Brueggemeier, Robert W.
Title: Aromatase expression and enzyme activity in breast cancer

Appavu K. Sundaram, PhD, 1997
Advisor: Curley, Robert W.
Title: Chemical and spectroscopic studies on retinoid microbial metabolites and retinoid/protein interactions

Pamela L. Boner, PhD, 1997
Advisor: Doskotch, Raymond W.
Title: Isolation and structural studies of natural products of solidago ohioensis riddell, amphiachyris dracunculoides (dc.) nutt., and ageratina colestinum l.

Thomas Gregory Urchek, PhD, 1997
Advisor: Olson, Carter L.
Title: The development and application of new instrumentation for mass transport studies

Anthony J. Lunato, PhD, 1996
Advisor: Soloway, Albert H.
Title: Part1: Synthesis and in vitro phosphorylation of a homologous series of 5-s-alkylcarboranyl-2'-deoxyuridines and 3-n-alkylcarboranyl- thymidines for use in boron neutron capture therapy of brain cancer: Part 2: an investigation into the stereoselective formation of 3,5-di-0-(p- toluoyl)-2-deoxy-(alpha)-D-ribofuranosyl chloride

Haiyan Pu, MS, 1996
Advisor: Robertson, Larry W.
Title: Antimicrobial and phytochemical investigation of Bidens Cernua L.

Michael J. Robarge, PhD, 1996
Advisor: Curley, Robert W.
Title: Stable analogues of retinoid-O-glucuronides : synthesis and biological activity

Patrick John Ward, PhD, 1996
Advisor: Brueggemeier, Robert W.
Title: Development of Steroidal Inhibitors of Cytochrome P450-Dependent Androgen and Estrogen Biosynthesis

Jill Marie O'Reilly, PhD, 1995
Advisor: Brueggemeier, Robert W.
Title: Synthesis and Biochemical Evaluation of a New Series of Aromatase Inhibitors: 7(alpha)-Arylaliphatic Androst-4-ene-3,17-diones and 7(alpha)-Arylaliphatic Androsta-1,4-diene-3,17-diones

Luz Minerva Burgos Fuster, MS, 1995
Advisor: Soloway, Albert H.
Title: Syntheses, characterizations and reactions involved in the preparations of boronated hydantoins

Xiaoyan Zhang , PhD, 1995
Advisor: Miller/Brueggemeier
Title: Design, Synthesis and Biological Activities of 4-Substituted Imidazoles as (alpha)2-Adrenoceptor Agonists

Joya Reena Hariharan, MS, 1994
Advisor: Soloway, Albert H.
Title: Design and synthesis of novel polyamine derivatives for boron neutron capture therapy for cancer

James Edward Romito, PhD, 1993
Advisor: Olson, Carter L.
Title: The design and development of a new instrument to monitor mass transport across membranes based on spatially resolved refractive index measurements

Robert Laurence Chapman, PhD, 1993
Advisor: Robertson, Larry W.
Title: Biologically active secondary metabolites of the fungus, Aspergillus flavipes

Michael J. Pcolinski, PhD, 1992
Advisor: Doskotch, Raymond W.
Title: Structural studies of natural products from Silphium perfoliatum L. Amphiachyris amoena (Shinner's) Solbrig and Amphiachyris dracunculoides DC. Nutt.

Mustapha Ahmed Beleh, PhD, 1992
Advisor: Brueggemeier, Robert W.
Title: Protein induction and estrogen metabolism in subcellular preparations and tissue slices of the golden Syrian hamster

Soheila Ebrahimian, PhD, 1992
Advisor: Brueggemeier, Robert W.
Title: Synthesis and biochemical evaluation of enzyme-activated irreversible aromatase inhibitors

Shu-Ling Liao, PhD, 1991
Advisor: Olson, Carter L.
Title: Part I : Use of a laser/photodiode array system to study transport of 4-nitrophenol across silicone rubber membranes; Part II : A generic microcomputer-based electroanalytical system

David A. Hartman, PhD, 1990
Advisor: Curley, Robert W.
Title: The synthesis, stereochemistry, and metabolic significance of ring-hydroxylated retinoids

James M. Chapman, PhD, 1990
Advisor: Curley, Robert W.
Title: The preparation and evaluation of immobilized retinoid analogues in the affinity chromatographic purification of retinoid binding proteins

Sanford Len Shew, PhD, 1990
Advisor: Olson, Carter L.
Title: Fluorescence lifetime studies of ligand-protein binding using the impulse response technique with refined data analysis methods