Education

• PhD Pharmaceutics 2002,The Ohio State University, Columbus, OH.
• BS Microbiology 1993, The Ohio State University, Columbus, OH.

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Areas of Interest

• Pharmacodynamics of various anti-cancer agents in vitro and in vivo. Developing rational approaches toward combination drug therapy for the treatment of cancer.

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Recent Publications

Wenqing Gao, Jeffrey S. Johnston, Duane D. Miller, and James T. Dalton, Interspecies differences in pharmacokinetics and metabolism of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)-propionamide: the role of N-acetyltransferase, Drug Metab. Dispos., 34:254-260, 2006.

Ekins S., Johnston J.S., Bahadduri P., D'Souza V.M., Ray A., Chang C., Swaan P.W. In Vitro and Pharmacophore-Based Discovery of Novel hPEPT1 Inhibitors. Pharm Res., 22(4):512-7, 2005.

Johnston, J.S., Johnson, A. L., Gan, Y., Wientjes, M.G., Au, J. L.-S. AZT Enhances Paclitaxel Activity in Human FaDu Cells. Pharm. Res., 20(7):957-961, 2003.

Naasani, I., Oh-Hashi, F., Oh-Hara, T., Feng, W.Y., Johnston, J., Chan, K., and Tsuruo, T. Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res., 63(4):824-30, 2003.

Mo, Y., Gan, Y., Song, S., Johnston, J., Xiao, X., Wientjes, M.G., and Au, J. L.-S. Simultaneous Targeting of Telomeres and Telomerase as a Cancer Therapeutic Approach. Cancer Res., 63:579-585, 2003.

Gan, Y., Mo, Y., Johnston, J., Lu, J., Wientjes, M.G., and Au, J. L.-S. Telomere maintenance in human ovarian SKOV-3 cells cannot be inhibited by telomerase inhibitors. FEBS Lett., 527:10-14, 2002.

Au, J.L.-S., Li, D., Gan, Y., Gao, X., Johnson, A., Johnston, J., Millenbaugh, N., Jang, S.H., Kuh, H.-J., and Wientjes, M.G. Pharmacodynamics of Immediate and Delayed Effects of Paclitaxel: Role of Slow Apoptosis and Intracellular Drug Retention. Cancer Res., 58:2141-2148, 1998.

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Book Chapters

Banerjee, A., Johnston, J.S., and Swaan, P.W. Carrier-mediated mechanisms for cellular drug transport, in Cellular Drug Delivery Principles and Practice, Lu, D. Robert and Øie, Svein [Eds.], Humana Press, 2004.

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Abstracts

Navin Wadehra, Teresa Lin, Timothy Ryan, Ashley Schneider, Allison Pepple, Jeffrey Johnston, James Dalton, Amy Banks, Charles F. Eisenbeis, Raymond Lai, John C. Byrd, Kristie Blum, Robert A. Baiocchi, Bortezomib (PS341, Velcade) and Rituximab Treatment Affects Multiple Survival and Death Pathways To Promote Apoptosis in Mantle Cell Lymphoma, The American Society of Hematology 48th Annual Meeting and Exposition, 2006
 
P Bahadduri, J Johnston, V D'Souza, A. Ray, PW Swaan and S Ekins.
Identification of Novel hPEPT1 Inhibitors by In Vitro and Pharmacophore
Based Approaches. AAPS Workshop on Drug Transporters in ADME: From the bench to the Bedside. Parsippany NJ, March 7-9, 2005

D’Souza, V.M., Johnston , J.S., Bahadurri, P., Ray, A., Swaan, P.W., and Ekins, S. In Vitro and pharmacophore based discovery of hPepT1 inhibitors. International Society for the Study of Xenobiotics, 2004.

Johnston , J. S. , Dalton, J. T., Swaan, P. W. Guggulsterone acts as a specific MRP1 inhibitor. The AAPS Journal, Volume 6, Issue S1, 2004.

Mo, Y., Gan, Y., Johnston, J.S., Song, S., Xiao, X., Wientjes, M.G., and Au, J. L.-S. Simultaneous Targeting of Telomeres and Telomerase as a Cancer Therapeutic Approach. Proc. Am. Cancer Res., 2002.

Gan, Y., Mo, Y., Johnston ,J. S., Lu, J., Wientjes, M.G., and Au, J. L.-S. Telomere Maintenance in Human Ovarian SKOV-3 Cells is Independent of Telomerase and Alternative Lengthening of Telomere. Proc. Am. Cancer Res., 2002.

Zhao, L., Wang, Y., Zuo, J., Johnston, J.S., Johnson, A. L., Au, J. L.-S., and Wientjes, M. G. A SAS Based Program to Evaluate Synergy-Application to Paclitaxel/Cisplatin Combinations. Proc. Am. Cancer Res., 2001

Johnston, J.S., Wientjes, M.G., and Au, J. L.-S. AZT Enhances Paclitaxel Activity in Human FaDu Cells. Proc. Am. Cancer Res., 2001.

Johnson, A.L., Schuller, D.E., Johnston, J.S., Grecula, J.C., and Au, J.L.-S. Interaction of Taxol, Radiation and Cisplatin in Human Head and Neck Cancer Cells. 4th International Conference on Head and Neck Cancer, Toronto, Canada, 1996.

Johnson, A.L., Johnston, J.S., Grecula, J.C., Schuller, D.E.,and Au, J.L.-S. Additive Cytotoxicity of Taxol and Radiation in Human Head and Neck Cancer Cells, Proc. Am. Cancer Res., 1996.

Johnson, A.L., Schuller, D.E., Johnston, J.S., Grecula, J.C., and Au, J.L-S. Interaction of Taxol, Radiation and Cisplatin in Human Head and Neck Cancer Cells. Proc. 1st Annual Update on Cancer Research Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Research Institute, The Ohio State University, Columbus, OH, 1996

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Courses Taught

Pharmacy 621(Drug Delivery I) Course Coordinator and Instructor:

Principles that govern the design and use of solution dosage forms, including physicochemical properties, ionization, solubility, and stability. Autumn Quarter, 3 credit hours. First-year Pharm.D. students.

Pharmacy 622 (Drug Delivery II) Instructor:

Routes of drug administration and the physiologic and physicochemical factors that influence drug penetration, absorption, and bioavailability. Winter Quarter, 3 credit hours. First-year Pharm.D. students.

Pharmacy 623 (Drug Delivery III) Instructor:

Application of physicochemical principles to the design, formulation, manufacture, and use of colloids, suspensions, emulsions, solid and topical drug delivery systems. Spring Quarter, 4 credit hours. First-year Pharm.D. students.

Pharmacy 724 (Pharmacogenomics) Course Coordinator and Instructor:

Principles and techniques necessary to understand the role of genetic variation in the pharmacokinetics of drugs and therapeutic management of disease. Winter Quarter, 3 credit hours. Third-year Pharm.D. students.

Pharmacy700D (Pharmacogenomics) Course Coordinator and Instructor:
An introduction to the topic of pharmacogenetics/pharmacogenomics and its implication in therapeutic management of disease. Autumn Quarter, 1 credit hour. NTPD students.

Pharmacy 694 (Drug discovery and development) Course Coordinator and Instructor:

This course introduces BS in Pharmaceutical Science (BSPS) students to research methods used for drug discovery and development in the field of pharmaceutics.  The course emphasizes drug discovery and development in contemporary pharmaceutics literature and research projects underway in division faculty research laboratories.  Each research-area presentation begins with relevant principles and background, followed by the research topic and its implications for the field of pharmaceutics and for drug therapeutics.  Students are expected to gain basic competencies in the topics covered and to understand the role of pharmaceutics in the drug development process and in improvement of drug therapy.   Spring Quarter, 3 credit hours. Rank 3 and rank 4 BSPS students.

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Professional Experience

2003-present Visiting Assistant Professor, The Ohio State University, College of Pharmacy, Division of Pharmaceutics, Columbus, OH.

2002-2003 Post-Doctoral Researcher, The Ohio State University, College of Pharmacy, Division of Pharmaceutics, Columbus, OH. (Advisor: Peter Swaan).

1999-2002 Graduatate Research Assistant, The Ohio State University, College of Pharmacy, Division of Pharmaceutics, Columbus, OH. (Advisor: Jessie Au).

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