Sylvan G. Frank, PhD

Professor and Associate Dean

217B Parks Hall
500 West 12th Ave.
Columbus, OH 43210-1291

E-mail: frank.1@osu.edu

Phone: (614) 292-6343,
Fax: (614) 292-7766 & (614) 292-9618

Dr. Frank Holds 5 patents in small particle formation and microencapsulation of relatively insoluble drugs. A fully endowed graduate fellowship in pharmaceutics was established in honor of Dr. Frank in 1997.

Education

• PhD Pharmaceutical Chemistry 1968, University of Michigan .
• MS Pharmaceutical Chemistry 1966, University of Michigan .
• BS Pharmacy 1962, Columbia University.

Areas of Interest

• The design and evaluation of novel drug delivery systems and the general application of surface and colloid chemistry to pharmaceutical systems.

  Current research interests include:

  • Small particle formation and microencapsulation
    
  • The kinetics and mechanisms of drug release from small particle systems
    
  • Solid dispersions, colloids, gels, and biocompatible matrixes
    
  • Solubilization; applications of percolation theory, fractal geometry and supercritical fluid technology to controlled drug delivery systems
    
  • Drug-excipient interactions
    
  • The fractal geometry of pharmaceutical systems
    
  • The phase behavior of complex systems
    
  • Iontophoresis.

Representative Publications

"Drug Release Studies on an Oil-Water Emulsion Based on a Eutectic Mixture of Lidocaine and Prilocaine as the Dispersed Phase," A.A. Nyquist-Mayer, A.F. Brodin and S.G. Frank, J. Pharm. Sci. 75:365-373 (1986).

"Drug Release from Emulsions Stabilized by Colloidal Microcrystalline Cellulose," K. Oza and S.G. Frank, J. Dispersion. Sci. Technol. 10(2):187-210 (1989).

"Penetration Temperatures of Aqueous Sodium Laurimonodipropionate Solutions into Solid Phytosterols," P. Tyle and S.G. Frank, J. Pharm. Sci. 80(2):201 (1991).

"Formation of Oil in Glycerol/Water Emulsions: Effect of Surfactant Ethylene Oxide Content," S. Magdassi and S.G. Frank, J. Dispersion. Sci. Technol. 11:519-528 (1990).

"Interaction of Lidocaine and Lidocaine Hydrochloride with the Liquid Crystal Structure of Topical Preparations," C.C. Mueller-Goymann and S.G. Frank, Inter. J. Pharm. 29:147-159 (1986).