- Virus-host interactions
- Structure and function of retroviral integrase
- Allosteric inhibitors of HIV-1 integrase
Dr. Kvaratskhelia’s research focuses on elucidating the molecular mechanisms for retroviral integration into the host genome, dissecting virus-host interactions, discovery of HIV-1 integrase inhibitors with allosteric mechanisms of action and developing retroviral vectors for human gene-therapy. His laboratory employs innovative and complementary biochemical, biophysical, structural biology, molecular biology and virology approaches.
After obtaining MS and PhD degrees in the former USSR, Dr. Kvaratskhelia received postdoctoral training with Dr. Roger Thorneley at the Department of Biological Chemistry, John Innes Center, England, UK (1995-1998) and with Dr. Malcolm White at the Department of Biochemistry, University of Dundee, Scotland, UK (1998-2000). Dr. Kvaratskhelia then worked as a Research Fellow in Dr. Stuart Le Grice’s laboratory (2000-2003) at HIV Drug Resistance Program, National Cancer Institute, Frederick, MD, USA before joining the Ohio State University College of Pharmacy and Center for Retrovirus Research in 2003 as a faculty member.
- 2016: Kimberly Professorship, The Ohio State University College of Pharmacy.
- 2007: Research Career Development Award, NIH/NIAID.
- J Biol Chem. 2014 Sep 19;289(38):26430-40
- J Virol. 2014 Sep 1;88(17):9704-17
- Nucleic Acids Res. 2014 Apr;42(8):4868-81
- Nucleic Acids Res. 2014;42(16):10209-25
- PLoS Pathog. 2014 May;10(5):e1004171
- Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41
- Curr Opin Chem Biol. 2013 Jun;17(3):339-45
- J Biol Chem. 2013 May 31;288(22):15813-20
- Proc Natl Acad Sci U S A. 2013 May 21;110(21):8690-5
- Nucleic Acids Res. 2013 Apr 1;41(6):3924-36