Professional Interests
Mitch Phelps’ group is involved in both pre-clinical and clinical development of numerous small molecule anti-cancer and immuno-modulatory agents under development here at OSU. Their work aims to understand the mechanisms involved in the absorption, distribution, metabolism, and excretion (i.e. pharmacokinetics, PK) of these agents, and how both the PK and pharmacodynamic (PD) effects of these agents are altered by genetic differences (polymorphisms) among individuals (i.e. pharmacogenetics, PG).
Recent Publications
- Mao, Y; Triantafillou, G; Hertlein, E; Towns, WH; Stefanovski, M; Mo, X; Jarjoura, D; Phelps, MA; Marcucci, G; Lee, LJ; Goldenberg, DM; Lee, RJ; John, BC; Muthusamy, N. Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carrier for Therapeutic Delivery in CD74+ B-Cell Malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 Dec 3;
- Spatola, RA; Thangavelu, M; Upadhyayula, V; Lee, S; Phelps, MA; Chandler, HL. Analysis of the transport of and cytotoxic effects for nalbuphine solution in corneal cells. American journal of veterinary research. 2012 Dec;73(12):1987-95
- Zhou, C; Zhang, Y; Yu, B; Phelps, MA; Lee, LJ; Lee, RJ. Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes. Nanomedicine : nanotechnology, biology, and medicine. 2012 Oct 29;
- He, L; Grecula, JC; Ling, Y; Enzerra, MD; Ammirati, M; Kendra, K; Cavaliere, R; Mayr, N; McGregor, J; Olencki, T; Mrozek, E; Matharbootham, M; Oluigbo, C; Phelps, MA. Development and validation of sensitive liquid chromatography/tandem mass spectrometry method for quantification of bendamustine in mouse brain tissue. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Aug 16;
- Menéndez, MI; Phelps, MA; Hothem, EA; Bertone, AL. Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses. American journal of veterinary research. 2012 Sep;73(9):1453-61
- Bill, MA; Nicholas, C; Mace, TA; Etter, JP; Li, C; Schwartz, EB; Fuchs, JR; Young, GS; Lin, L; Lin, J; He, L; Phelps, M; Li, PK; Lesinski, GB. Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines. PloS one. 2012;7(8):e40724
- Mortazavi, A; Ling, Y; Martin, LK; Wei, L; Phelps, MA; Liu, Z; Harper, EJ; Ivy, SP; Wu, X; Zhou, BS; Liu, X; Deam, D; Monk, JP; Hicks, WJ; Yen, Y; Otterson, GA; Grever, MR; Bekaii-Saab, T. A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors. Investigational new drugs. 2012 Jul 31;
- Nuovo, GJ; Garofalo, M; Valeri, N; Roulstone, V; Volinia, S; Cohn, DE; Phelps, M; Harrington, KJ; Vile, R; Melcher, A; Galanis, E; Sehl, S; Adair, R; Scott, K; Rose, A; Toogood, G; Coffey, MC. Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2012 Jun 15;
- Holpuch, AS; Phelps, MP; Desai, KG; Chen, W; Koutras, GM; Han, BB; Warner, BM; Pei, P; Seghi, GA; Tong, M; Border, MB; Fields, HW; Stoner, GD; Larsen, PE; Liu, Z; Schwendeman, SP; Mallery, SR. Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention. Carcinogenesis. 2012 May;33(5):1098-105
- Dulin, JA; Drost, WT; Phelps, MA; Santschi, EM; Menendez, MI; Bertone, AL. Influence of exercise on the distribution of technetium Tc 99m medronate following intra-articular injection in horses. American journal of veterinary research. 2012 Mar;73(3):418-25
Education
- Ph.D., 2005, The Ohio State University, Biophysics
- MLHR, 1999, The Ohio State University, Business Management/Labor and Human Resources
- B.A., 1992, Ohio Wesleyan University, Physics
