Professional Interests
The research area of Dr. Li focuses in the design, synthesis and biochemical testing of steroidal and non-steroidal steroid sulfatase inhibitors as potential agents for the treatment of hormone-dependent cancers. Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than estrogen levels in plasma, presumably due to in situ formation of estrogen. The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. One of their goals is to develop potent estrone sulfatase inhibitors as potential agents for the treatment of estrogen-dependent breast cancer. They have synthesized both the steroidal and non-steroidal estrone sulfatase inhibitors.
Recent Publications
- Bill, MA; Nicholas, C; Mace, TA; Etter, JP; Li, C; Schwartz, EB; Fuchs, JR; Young, GS; Lin, L; Lin, J; He, L; Phelps, M; Li, PK; Lesinski, GB. Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines. PloS one. 2012;7(8):e40724
- Sen, M; Thomas, SM; Kim, S; Yeh, JI; Ferris, RL; Johnson, JT; Duvvuri, U; Lee, J; Sahu, N; Joyce, S; Freilino, ML; Shi, H; Li, C; Ly, D; Rapireddy, S; Etter, JP; Li, PK; Wang, L; Chiosea, S; Seethala, RR; Gooding, WE; Chen, X; Kaminski, N; Pandit, K; Johnson, DE; Grandis, JR. First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy. Cancer discovery. 2012 Aug;2(8):694-705
- Agudelo-Garcia, PA; De, Jesus, JK; Williams, SP; Nowicki, MO; Chiocca, EA; Liyanarachchi, S; Li, PK; Lannutti, JJ; Johnson, JK; Lawler, SE; Viapiano, MS. Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia (New York, N.Y.). 2011 Sep;13(9):831-40
- Lin, L; Liu, A; Peng, Z; Lin, HJ; Li, PK; Li, C; Lin, J. STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer research. 2011 Dec 1;71(23):7226-37
- Wu, X; Wang, L; Han, Y; Regan, N; Li, PK; Villalona, MA; Hu, X; Briesewitz, R; Pei, D. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS combinatorial science. 2011 Sep 12;13(5):486-95
- Liu, A; Liu, Y; Li, PK; Li, C; Lin, J. LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells. Anticancer research. 2011 Jun;31(6):2029-35
- Lin, L; Liu, Y; Li, H; Li, PK; Fuchs, J; Shibata, H; Iwabuchi, Y; Lin, J. Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. British journal of cancer. 2011 Jul 12;105(2):212-20
- Fossey, SL; Bear, MD; Lin, J; Li, C; Schwartz, EB; Li, PK; Fuchs, JR; Fenger, J; Kisseberth, WC; London, CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC cancer. 2011 Mar 28;11:112
- Abdel-Rahman, MH; Yang, Y; Salem, MM; Meadows, S; Massengill, JB; Li, PK; Davidorf, FH. Investigation of the potential utility of a linomide analogue for treatment of choroidal neovascularization. Experimental eye research. 2010 Dec;91(6):837-43
- Lin, L; Deangelis, S; Foust, E; Fuchs, J; Li, C; Li, PK; Schwartz, EB; Lesinski, GB; Benson, D; Lü, J; Hoyt, D; Lin, J. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Molecular cancer. 2010 Aug 16;9:217
Honors
- 1997 President's Award for Excellence
- 1997 School of Pharmacy Award for Excellence in Scholarship
- 1988 Distinguished Presentation of the 14th annual meeting, Graduate Student Forum
- 1987 University Graduate Associate Teaching Award
- 1983-1984 University Fellowship
Education
- Ph.D., 1988, The Ohio State University
- B.S., 1983, University of Wyoming
