Professional Interests
Natural products have always played a key role for medicinal chemists in the process of drug discovery. Employing the structural scaffolds and biological activity of these compounds as a starting point, our group intends to use synthetic chemistry as a tool to probe biological problems. Specifically, in Dr. Fuch’s lab they will utilize synthetic methods to prepare these bioactive natural products and their analogues, gain insight into the structure–activity relationships of ligand/receptor systems, and investigate biosynthetic pathways. Ultimately, the goal is not simply to prepare these natural products, but to improve upon their activity and pharmacological profiles.
Recent Publications
- Wang, H; Jurado, KA; Wu, X; Shun, MC; Li, X; Ferris, AL; Smith, SJ; Patel, PA; Fuchs, JR; Cherepanov, P; Kvaratskhelia, M; Hughes, SH; Engelman, A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic acids research. 2012 Oct 5;
- Bill, MA; Nicholas, C; Mace, TA; Etter, JP; Li, C; Schwartz, EB; Fuchs, JR; Young, GS; Lin, L; Lin, J; He, L; Phelps, M; Li, PK; Lesinski, GB. Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines. PloS one. 2012;7(8):e40724
- Pan, L; Lezama-Davila, CM; Isaac-Marquez, AP; Calomeni, EP; Fuchs, JR; Satoskar, AR; Kinghorn, AD. Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii. Phytochemistry. 2012 Oct;82:128-35
- Kessl, JJ; Jena, N; Koh, Y; Taskent-Sezgin, H; Slaughter, A; Feng, L; de, Silva, S; Wu, L; Le, Grice, SF; Engelman, A; Fuchs, JR; Kvaratskhelia, M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of biological chemistry. 2012 May 11;287(20):16801-11
- Fossey, SL; Bear, MD; Lin, J; Li, C; Schwartz, EB; Li, PK; Fuchs, JR; Fenger, J; Kisseberth, WC; London, CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC cancer. 2011 Mar 28;11:112
- Ren, Y; Matthew, S; Lantvit, DD; Ninh, TN; Chai, H; Fuchs, JR; Soejarto, DD; de, Blanco, EJ; Swanson, SM; Kinghorn, AD. Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues. Journal of natural products. 2011 May 27;74(5):1117-25
- Vijaya, Saradhi, UV; Ling, Y; Wang, J; Chiu, M; Schwartz, EB; Fuchs, JR; Chan, KK; Liu, Z. A liquid chromatography-tandem mass spectrometric method for quantification of curcuminoids in cell medium and mouse plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Nov 15;878(30):3045-51
- Bill, MA; Fuchs, JR; Li, C; Yui, J; Bakan, C; Benson, DM, Jr; Schwartz, EB; Abdelhamid, D; Lin, J; Hoyt, DG; Fossey, SL; Young, GS; Carson, WE, 3rd; Li, PK; Lesinski, GB. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular cancer. 2010 Jun 25;9:165
- Cen, L; Hutzen, B; Ball, S; DeAngelis, S; Chen, CL; Fuchs, JR; Li, C; Li, PK; Lin, J. New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. BMC cancer. 2009 Mar 30;9:99
- Fuchs, JR; Pandit, B; Bhasin, D; Etter, JP; Regan, N; Abdelhamid, D; Li, C; Lin, J; Li, PK. Structure-activity relationship studies of curcumin analogues. Bioorganic & medicinal chemistry letters. 2009 Apr 1;19(7):2065-9
Education
- Postdoctoral, 2007, The Scripps Research Institute
- Ph.D., 2005, The Pennsylvania State University, Organic Chemistry
- B.S., 1998, University of Toledo, Chemistry
