Professional Interests
Dr. Curley's primary research interests lie in the area of the medicinal chemistry and biochemistry of important vitamin A metabolites with potential to function as cancer chemopreventive agents. A secondary interest involves developing strategies for the synthesis of stable isotope-labelled molecules to facilitate NMR structural studies of drug-receptor interactions and of receptor proteins themselves.
Recent Publications
- Eroglu, A; Hruszkewycz, DP; dela, Sena, C; Narayanasamy, S; Riedl, KM; Kopec, RE; Schwartz, SJ; Curley, RW, Jr; Harrison, EH. Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. The Journal of biological chemistry. 2012 May 4;287(19):15886-95
- Curley, RW, Jr. Retinoid chemistry: synthesis and application for metabolic disease. Biochimica et biophysica acta. 2012 Jan;1821(1):3-9
- Fleshman, MK; Lester, GE; Riedl, KM; Kopec, RE; Narayanasamy, S; Curley, RW, Jr; Schwartz, SJ; Harrison, EH. Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons: determinations of β-carotene bioaccessibility and bioavailability. Journal of agricultural and food chemistry. 2011 May 11;59(9):4448-54
- Soloway, AH; Curley, RW, Jr; Soloway, SM. Macular degeneration: a possible biochemical mechanism. Medical hypotheses. 2011 May;76(5):729-32
- Eroglu, A; Hruszkewycz, DP; Curley, RW, Jr; Harrison, EH. The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα. Archives of biochemistry and biophysics. 2010 Dec 1;504(1):11-6
- Marsh, RS; Yan, Y; Reed, VM; Hruszkewycz, D; Curley, RW; Harrison, EH. {beta}-Apocarotenoids do not significantly activate retinoic acid receptors {alpha} or {beta}. Experimental biology and medicine (Maywood, N.J.). 2010 Mar;235(3):342-8
- Kopec, RE; Riedl, KM; Harrison, EH; Curley, RW, Jr; Hruszkewycz, DP; Clinton, SK; Schwartz, SJ. Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. Journal of agricultural and food chemistry. 2010 Mar 24;58(6):3290-6
- Su, B; Mershon, SM; Stonerock, LA; Curley, RW, Jr; Brueggemeier, RW. 4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells. The Journal of steroid biochemistry and molecular biology. 2008 Mar;109(1-2):40-6
- Mershon, SM; Anding, AL; Chapman, JS; Clagett-Dame, M; Stonerock, LA; Curley, RW, Jr. Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs. Bioorganic & medicinal chemistry letters. 2007 Feb 1;17(3):836-40
- Walker, JR; Alshafie, G; Nieves, N; Ahrens, J; Clagett-Dame, M; Abou-Issa, H; Curley, RW, Jr. Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide. Bioorganic & medicinal chemistry. 2006 May 1;14(9):3038-48
Honors
- 2009 AAPS Fellow
- 1993-1994 Pfeiffer Memorial Fellowship, American Foundation for Pharmaceutical Education
- 1982-1984 National Research Service Fellowship, National Cancer Institute
- 1981-1982 Abe Plough Citation Fellow, American Foundation for Pharmaceutical Education
- 1979-1981 American Foundation for Pharmaceutical Education Fellowships
- 1973-1975 Melvin A. Prawdzik Memorial Scholarships
Education
- Postdoctoral, 1984, University of Wisconsin
- Ph.D., 1982, West Virginia University, Pharmaceutical Sciences
- B.S., 1978, University Of Connecticut, Pharmacy
